Effect of PTH and corticotomy on implant movement under mechanical force
Abstract Background Osseointegrated implants are considered as clinically non-movable. Parathyroid hormone (PTH) is known to play a significant role in the regulation of bone remodeling and in intermittent, low doses, result in osteoanabolic effects. This study aimed to investigate the effects of PT...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Oral Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12903-020-01310-4 |
| _version_ | 1818436986635026432 |
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| author | Jiyeon Kim Heon-Young Kim Won-Ho Kim Jin-Woo Kim Min-Ji Kim |
| author_facet | Jiyeon Kim Heon-Young Kim Won-Ho Kim Jin-Woo Kim Min-Ji Kim |
| author_sort | Jiyeon Kim |
| collection | DOAJ |
| description | Abstract Background Osseointegrated implants are considered as clinically non-movable. Parathyroid hormone (PTH) is known to play a significant role in the regulation of bone remodeling and in intermittent, low doses, result in osteoanabolic effects. This study aimed to investigate the effects of PTH and corticotomy, both under traction force, on osseointegrated implants. Methods Four implants—two in each hemimandible—were placed in each of the three study mongrels. Each mongrels were designated as control, normal dose PTH (PTH-1), and high dose PTH (PTH-2) groups, with each groups further subdivided into non-surgery implant and surgery implant. After osseointegration, mechanical force with NiTi closed coil springs (500 g) was applied around each implants. Corticotomy was performed around one of four implants in each mongrels. Parathyroid hormone was administered locally on a weekly basis for 20 weeks. Clinical movement of the implants were evaluated with the superimposed 3D- scanned data, bone- microarchitectural and histologic examinations. Results Superimposition analysis showed continuous movement of the non-surgery implant of PTH-1 group. Movement was further justified with lowest bone implant contact (adjusted BIC; 44.77%) in histomorphometric analysis. Upregulation of bone remodeling around the implant was observed in the normal dose PTH group. In the surgery implants, the remarkably higher adjusted BIC compared to the non-surgery implants indicated increased bone formation around the implant surface. Conclusion The results indicate that the catabolic and anabolic balance of osseointegrated implants in terms of bone remodeling can be shifted via various interventions including pharmacological, surgical and mechanical force. Clinical relevance Upregulated bone remodeling by PTH and corticotomy under continuous mechanical force showed the possible implications for the movement of osseointegrated dental implant. |
| first_indexed | 2024-12-14T17:17:30Z |
| format | Article |
| id | doaj.art-f6d9bcbfe805437dab59551599d53582 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-12-14T17:17:30Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-f6d9bcbfe805437dab59551599d535822022-12-21T22:53:24ZengBMCBMC Oral Health1472-68312020-11-0120111010.1186/s12903-020-01310-4Effect of PTH and corticotomy on implant movement under mechanical forceJiyeon Kim0Heon-Young Kim1Won-Ho Kim2Jin-Woo Kim3Min-Ji Kim4School of Medicine, Ewha Womans UniversityDepartment of Oral and Maxillofacial Surgery, School of Medicine, Ewha Womans UniversityDepartment of Orthodontics, School of Medicine, Ewha Womans UniversityDepartment of Oral and Maxillofacial Surgery, School of Medicine, Ewha Womans UniversityDepartment of Orthodontics, School of Medicine, Ewha Womans UniversityAbstract Background Osseointegrated implants are considered as clinically non-movable. Parathyroid hormone (PTH) is known to play a significant role in the regulation of bone remodeling and in intermittent, low doses, result in osteoanabolic effects. This study aimed to investigate the effects of PTH and corticotomy, both under traction force, on osseointegrated implants. Methods Four implants—two in each hemimandible—were placed in each of the three study mongrels. Each mongrels were designated as control, normal dose PTH (PTH-1), and high dose PTH (PTH-2) groups, with each groups further subdivided into non-surgery implant and surgery implant. After osseointegration, mechanical force with NiTi closed coil springs (500 g) was applied around each implants. Corticotomy was performed around one of four implants in each mongrels. Parathyroid hormone was administered locally on a weekly basis for 20 weeks. Clinical movement of the implants were evaluated with the superimposed 3D- scanned data, bone- microarchitectural and histologic examinations. Results Superimposition analysis showed continuous movement of the non-surgery implant of PTH-1 group. Movement was further justified with lowest bone implant contact (adjusted BIC; 44.77%) in histomorphometric analysis. Upregulation of bone remodeling around the implant was observed in the normal dose PTH group. In the surgery implants, the remarkably higher adjusted BIC compared to the non-surgery implants indicated increased bone formation around the implant surface. Conclusion The results indicate that the catabolic and anabolic balance of osseointegrated implants in terms of bone remodeling can be shifted via various interventions including pharmacological, surgical and mechanical force. Clinical relevance Upregulated bone remodeling by PTH and corticotomy under continuous mechanical force showed the possible implications for the movement of osseointegrated dental implant.http://link.springer.com/article/10.1186/s12903-020-01310-4ImplantBone remodelingParathyroid hormoneCorticotomyOrthodontic force |
| spellingShingle | Jiyeon Kim Heon-Young Kim Won-Ho Kim Jin-Woo Kim Min-Ji Kim Effect of PTH and corticotomy on implant movement under mechanical force BMC Oral Health Implant Bone remodeling Parathyroid hormone Corticotomy Orthodontic force |
| title | Effect of PTH and corticotomy on implant movement under mechanical force |
| title_full | Effect of PTH and corticotomy on implant movement under mechanical force |
| title_fullStr | Effect of PTH and corticotomy on implant movement under mechanical force |
| title_full_unstemmed | Effect of PTH and corticotomy on implant movement under mechanical force |
| title_short | Effect of PTH and corticotomy on implant movement under mechanical force |
| title_sort | effect of pth and corticotomy on implant movement under mechanical force |
| topic | Implant Bone remodeling Parathyroid hormone Corticotomy Orthodontic force |
| url | http://link.springer.com/article/10.1186/s12903-020-01310-4 |
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