Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study
BackgroundLimited studies have explored the association between sexual factors [age at first sexual intercourse (AFS) and lifetime number of sexual partners (LNSP)] and cardiovascular diseases (CVDs), leaving the causality inconclusive.MethodsWe performed a bi-directional Mendelian randomization (MR...
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| Format: | Article |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1267906/full |
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| author | Chengui Zhuo Lei Chen Qiqi Wang Haipeng Cai Zujin Lin Huili Pan Meicui Wu Yuxiang Jin Hong Jin Liangrong Zheng |
| author_facet | Chengui Zhuo Lei Chen Qiqi Wang Haipeng Cai Zujin Lin Huili Pan Meicui Wu Yuxiang Jin Hong Jin Liangrong Zheng |
| author_sort | Chengui Zhuo |
| collection | DOAJ |
| description | BackgroundLimited studies have explored the association between sexual factors [age at first sexual intercourse (AFS) and lifetime number of sexual partners (LNSP)] and cardiovascular diseases (CVDs), leaving the causality inconclusive.MethodsWe performed a bi-directional Mendelian randomization (MR) study to investigate the causality between sexual factors and CVDs, including coronary artery disease, myocardial infarction, atrial fibrillation (AF), heart failure (HF), and ischemic stroke (IS). Single-nucleotide polymorphisms (SNPs) for sexual factors were extracted from the UK Biobank. Statistics for each CVD were derived from two different databases. MR estimates were calculated per outcome database and were combined through meta-analysis. Several complementary sensitivity analyses were also performed.ResultsThe primary analysis suggested that AFS was causally associated with the risk of CVDs; the odds ratios (ORs) ranged from 0.686 [95% confidence interval (CI), 0.611–0.770] for HF to 0.798 (95% CI, 0.719–0.886) for AF. However, the association between AFS and IS (OR, 0.844; 95% CI, 0.632–1.126) was not consistent in the meta-analysis after excluding SNPs related to confounders. Moreover, non-significant associations were found between LNSP and CVDs. Reverse direction MR analysis showed that CVDs were not associated with sexual factors.ConclusionsGenetic evidence suggested that AFS was causally associated with the risk of CVDs except for IS, whereas non-significant association of LNSP with CVDs was detected. Further investigation into AFS could be warranted in preventing the progression of CVDs. |
| first_indexed | 2024-03-09T02:10:19Z |
| format | Article |
| id | doaj.art-f6da2b0967534d79a4055f872c2c1a0b |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-09T02:10:19Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-f6da2b0967534d79a4055f872c2c1a0b2023-12-07T13:25:39ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-12-011010.3389/fcvm.2023.12679061267906Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization studyChengui Zhuo0Lei Chen1Qiqi Wang2Haipeng Cai3Zujin Lin4Huili Pan5Meicui Wu6Yuxiang Jin7Hong Jin8Liangrong Zheng9Department of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaZhejiang Provincial Center for Drug and Medical Device Procurement, Hangzhou, ChinaDepartment of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Cardiology and Atrial Fibrillation Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaBackgroundLimited studies have explored the association between sexual factors [age at first sexual intercourse (AFS) and lifetime number of sexual partners (LNSP)] and cardiovascular diseases (CVDs), leaving the causality inconclusive.MethodsWe performed a bi-directional Mendelian randomization (MR) study to investigate the causality between sexual factors and CVDs, including coronary artery disease, myocardial infarction, atrial fibrillation (AF), heart failure (HF), and ischemic stroke (IS). Single-nucleotide polymorphisms (SNPs) for sexual factors were extracted from the UK Biobank. Statistics for each CVD were derived from two different databases. MR estimates were calculated per outcome database and were combined through meta-analysis. Several complementary sensitivity analyses were also performed.ResultsThe primary analysis suggested that AFS was causally associated with the risk of CVDs; the odds ratios (ORs) ranged from 0.686 [95% confidence interval (CI), 0.611–0.770] for HF to 0.798 (95% CI, 0.719–0.886) for AF. However, the association between AFS and IS (OR, 0.844; 95% CI, 0.632–1.126) was not consistent in the meta-analysis after excluding SNPs related to confounders. Moreover, non-significant associations were found between LNSP and CVDs. Reverse direction MR analysis showed that CVDs were not associated with sexual factors.ConclusionsGenetic evidence suggested that AFS was causally associated with the risk of CVDs except for IS, whereas non-significant association of LNSP with CVDs was detected. Further investigation into AFS could be warranted in preventing the progression of CVDs.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1267906/fullage at first sexual intercourselifetime number of sexual partnerscardiovascular diseasescausal associationMendelian randomization |
| spellingShingle | Chengui Zhuo Lei Chen Qiqi Wang Haipeng Cai Zujin Lin Huili Pan Meicui Wu Yuxiang Jin Hong Jin Liangrong Zheng Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study Frontiers in Cardiovascular Medicine age at first sexual intercourse lifetime number of sexual partners cardiovascular diseases causal association Mendelian randomization |
| title | Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study |
| title_full | Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study |
| title_fullStr | Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study |
| title_full_unstemmed | Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study |
| title_short | Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study |
| title_sort | association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases a bi directional mendelian randomization study |
| topic | age at first sexual intercourse lifetime number of sexual partners cardiovascular diseases causal association Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1267906/full |
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