Mycobacteria-Specific Mono- and Polyfunctional CD4+ T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study

Mycobacteria-Specific Mono- and Polyfunctional CD4+ T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study

Background: Current immune-based TB tests, including the tuberculin skin test (TST) and interferon-gamma release assays (IGRA), have significant limitations, including the inability to distinguish between latent TB infection (LTBI) and active TB. Few biomarkers with the potential to discriminate bet...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Marc Tebruegge, Nicole Ritz, Susan Donath, Binita Dutta, Benjamin Forbes, Vanessa Clifford, Christel Zufferey, Robert De Rose, Roy M. Robins-Browne, Willem Hanekom, Stephen M. Graham, Tom Connell, Nigel Curtis
التنسيق: مقال
اللغة:English
منشور في: Frontiers Media S.A. 2019-04-01
سلاسل:Frontiers in Immunology
الموضوعات:
tuberculosis
child
immunoassay
functional profile
T cell
diagnosis
الوصول للمادة أونلاين:https://www.frontiersin.org/article/10.3389/fimmu.2019.00431/full

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