Mycobacteria-Specific Mono- and Polyfunctional CD4+ T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study

Mycobacteria-Specific Mono- and Polyfunctional CD4+ T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study

Background: Current immune-based TB tests, including the tuberculin skin test (TST) and interferon-gamma release assays (IGRA), have significant limitations, including the inability to distinguish between latent TB infection (LTBI) and active TB. Few biomarkers with the potential to discriminate bet...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Marc Tebruegge, Nicole Ritz, Susan Donath, Binita Dutta, Benjamin Forbes, Vanessa Clifford, Christel Zufferey, Robert De Rose, Roy M. Robins-Browne, Willem Hanekom, Stephen M. Graham, Tom Connell, Nigel Curtis
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2019-04-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
tuberculosis
child
immunoassay
functional profile
T cell
diagnosis
Online Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2019.00431/full

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