Blood and lymphatic systems are segregated by the FLCN tumor suppressor
Blood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endoth...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20156-6 |
| _version_ | 1818749700633788416 |
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| author | Ikue Tai-Nagara Yukiko Hasumi Dai Kusumoto Hisashi Hasumi Keisuke Okabe Tomofumi Ando Fumio Matsuzaki Fumiko Itoh Hideyuki Saya Chang Liu Wenling Li Yoh-suke Mukouyama W. Marston Linehan Xinyi Liu Masanori Hirashima Yutaka Suzuki Shintaro Funasaki Yorifumi Satou Mitsuko Furuya Masaya Baba Yoshiaki Kubota |
| author_facet | Ikue Tai-Nagara Yukiko Hasumi Dai Kusumoto Hisashi Hasumi Keisuke Okabe Tomofumi Ando Fumio Matsuzaki Fumiko Itoh Hideyuki Saya Chang Liu Wenling Li Yoh-suke Mukouyama W. Marston Linehan Xinyi Liu Masanori Hirashima Yutaka Suzuki Shintaro Funasaki Yorifumi Satou Mitsuko Furuya Masaya Baba Yoshiaki Kubota |
| author_sort | Ikue Tai-Nagara |
| collection | DOAJ |
| description | Blood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endothelial cells. |
| first_indexed | 2024-12-18T04:07:57Z |
| format | Article |
| id | doaj.art-f6dbc6531325464ea278f5550b28f758 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:07:57Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f6dbc6531325464ea278f5550b28f7582022-12-21T21:21:33ZengNature PortfolioNature Communications2041-17232020-12-0111111210.1038/s41467-020-20156-6Blood and lymphatic systems are segregated by the FLCN tumor suppressorIkue Tai-Nagara0Yukiko Hasumi1Dai Kusumoto2Hisashi Hasumi3Keisuke Okabe4Tomofumi Ando5Fumio Matsuzaki6Fumiko Itoh7Hideyuki Saya8Chang Liu9Wenling Li10Yoh-suke Mukouyama11W. Marston Linehan12Xinyi Liu13Masanori Hirashima14Yutaka Suzuki15Shintaro Funasaki16Yorifumi Satou17Mitsuko Furuya18Masaya Baba19Yoshiaki Kubota20Department of Anatomy, Keio University School of MedicineDepartment of Ophthalmology, Yokohama City University Graduate School of MedicineDepartment of Cardiology, Keio University School of MedicineUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of HealthDepartment of Anatomy, Keio University School of MedicineDepartment of Anatomy, Keio University School of MedicineLaboratory for Cell Asymmetry, RIKEN Center for Biosystems Dynamics ResearchLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life SciencesDivision of Gene Regulation, Institute for Advanced Medical Research, Keio University School of MedicineLaboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of HealthLaboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of HealthLaboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of HealthUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of HealthDivision of Pharmacology, Niigata University Graduate School of Medical and Dental SciencesDivision of Pharmacology, Niigata University Graduate School of Medical and Dental SciencesDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of TokyoLaboratory of Cancer Metabolism, International Research Center for Medical Sciences, Kumamoto UniversityDivision of Genomics and Transcriptomics Joint Research Center for Human Retrovirus Infection, Kumamoto and Kagoshima UniversitiesDepartment of Molecular Pathology, Yokohama City University Graduate School of MedicineUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of HealthDepartment of Anatomy, Keio University School of MedicineBlood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endothelial cells.https://doi.org/10.1038/s41467-020-20156-6 |
| spellingShingle | Ikue Tai-Nagara Yukiko Hasumi Dai Kusumoto Hisashi Hasumi Keisuke Okabe Tomofumi Ando Fumio Matsuzaki Fumiko Itoh Hideyuki Saya Chang Liu Wenling Li Yoh-suke Mukouyama W. Marston Linehan Xinyi Liu Masanori Hirashima Yutaka Suzuki Shintaro Funasaki Yorifumi Satou Mitsuko Furuya Masaya Baba Yoshiaki Kubota Blood and lymphatic systems are segregated by the FLCN tumor suppressor Nature Communications |
| title | Blood and lymphatic systems are segregated by the FLCN tumor suppressor |
| title_full | Blood and lymphatic systems are segregated by the FLCN tumor suppressor |
| title_fullStr | Blood and lymphatic systems are segregated by the FLCN tumor suppressor |
| title_full_unstemmed | Blood and lymphatic systems are segregated by the FLCN tumor suppressor |
| title_short | Blood and lymphatic systems are segregated by the FLCN tumor suppressor |
| title_sort | blood and lymphatic systems are segregated by the flcn tumor suppressor |
| url | https://doi.org/10.1038/s41467-020-20156-6 |
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