Cortical thickness abnormalities in long-term remitted cushing’s disease
Introduction Remitted Cushing’s disease (RCD)-patients commonly continue to present persistent psychological and cognitive deficits, and alterations in brain function and structure. Assessing cortical thickness and surface area of RCD-patients may offer further insight into the neuroanatomical sub...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821003631/type/journal_article |
| _version_ | 1797616824473354240 |
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| author | S. Bauduin Z. Van Der Pal A. Pereira O. Meijer E. Giltay N. Van Der Wee S. Van Der Werff |
| author_facet | S. Bauduin Z. Van Der Pal A. Pereira O. Meijer E. Giltay N. Van Der Wee S. Van Der Werff |
| author_sort | S. Bauduin |
| collection | DOAJ |
| description |
Introduction
Remitted Cushing’s disease (RCD)-patients commonly continue to present persistent psychological and cognitive deficits, and alterations in brain function and structure. Assessing cortical thickness and surface area of RCD-patients may offer further insight into the neuroanatomical substrates of Cushing’s disease.
Objectives
To assess cortical thickness and surface area in RCD-patients in comparison to healthy controls (HCs).
Methods
Structural 3T MRI’s were obtained from 25 long-term RCD-patients, and 25 age-, gender-, and education-matched HCs. T1-weighted images were segmented to extract mean cortical thickness and surface area values of 68 cortical gray matter regions. Paired sample t-tests explored differences between the anterior cingulate cortex (ACC; region of interest), and the whole brain. Validated scales assessed psychiatric symptomatology, self-reported cognitive functioning, and disease severity.
Results
After correction for multiple comparisons, ROI analyses indicated that RCD-patients showed reduced cortical thickness of the left caudal ACC and the right rostral ACC compared to HCs. Whole-brain analyses indicated thinner cortices of the left caudal ACC, left cuneus, left posterior cingulate cortex, right rostral ACC, and bilateral precuneus compared to HCs. No cortical surface area differences were identified. Cortical thickness of the left caudal ACC was inversely associated with anxiety symptoms and disease duration.
Conclusions
In six of 68 regions examined, RCD patients had reduced cortical thickness in comparison to HCs. Cortical thickness of the left caudal ACC was inversely associated with disease duration, suggesting that prolonged and excessive exposure to glucocorticoids may be related to cortical thinning of brain structures involved in emotional and cognitive processing.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:46:49Z |
| format | Article |
| id | doaj.art-f6dc1b85522a4a7da951684565efce63 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:46:49Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-f6dc1b85522a4a7da951684565efce632023-11-17T05:07:37ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S130S13010.1192/j.eurpsy.2021.363Cortical thickness abnormalities in long-term remitted cushing’s diseaseS. Bauduin0Z. Van Der Pal1A. Pereira2O. Meijer3E. Giltay4N. Van Der Wee5S. Van Der Werff6Department Of Psychiatry, Leiden University Medical Center, Leiden, NetherlandsDepartment Of Psychiatry, Leiden University Medical Center, Leiden, NetherlandsDepartment Of Endocrinology, Leiden University Medical Center, Leiden, NetherlandsDepartment Of Endocrinology, Leiden University Medical Center, Leiden, NetherlandsDepartment Of Psychiatry, Leiden University Medical Center, Leiden, NetherlandsDepartment Of Psychiatry, Leiden University Medical Center, Leiden, NetherlandsDepartment Of Psychiatry, Leiden University Medical Center, Leiden, Netherlands Introduction Remitted Cushing’s disease (RCD)-patients commonly continue to present persistent psychological and cognitive deficits, and alterations in brain function and structure. Assessing cortical thickness and surface area of RCD-patients may offer further insight into the neuroanatomical substrates of Cushing’s disease. Objectives To assess cortical thickness and surface area in RCD-patients in comparison to healthy controls (HCs). Methods Structural 3T MRI’s were obtained from 25 long-term RCD-patients, and 25 age-, gender-, and education-matched HCs. T1-weighted images were segmented to extract mean cortical thickness and surface area values of 68 cortical gray matter regions. Paired sample t-tests explored differences between the anterior cingulate cortex (ACC; region of interest), and the whole brain. Validated scales assessed psychiatric symptomatology, self-reported cognitive functioning, and disease severity. Results After correction for multiple comparisons, ROI analyses indicated that RCD-patients showed reduced cortical thickness of the left caudal ACC and the right rostral ACC compared to HCs. Whole-brain analyses indicated thinner cortices of the left caudal ACC, left cuneus, left posterior cingulate cortex, right rostral ACC, and bilateral precuneus compared to HCs. No cortical surface area differences were identified. Cortical thickness of the left caudal ACC was inversely associated with anxiety symptoms and disease duration. Conclusions In six of 68 regions examined, RCD patients had reduced cortical thickness in comparison to HCs. Cortical thickness of the left caudal ACC was inversely associated with disease duration, suggesting that prolonged and excessive exposure to glucocorticoids may be related to cortical thinning of brain structures involved in emotional and cognitive processing. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821003631/type/journal_articleNeuroimagingCushing’s DiseaseendocrinologyPsychiatric symptomatology |
| spellingShingle | S. Bauduin Z. Van Der Pal A. Pereira O. Meijer E. Giltay N. Van Der Wee S. Van Der Werff Cortical thickness abnormalities in long-term remitted cushing’s disease European Psychiatry Neuroimaging Cushing’s Disease endocrinology Psychiatric symptomatology |
| title | Cortical thickness abnormalities in long-term remitted cushing’s disease |
| title_full | Cortical thickness abnormalities in long-term remitted cushing’s disease |
| title_fullStr | Cortical thickness abnormalities in long-term remitted cushing’s disease |
| title_full_unstemmed | Cortical thickness abnormalities in long-term remitted cushing’s disease |
| title_short | Cortical thickness abnormalities in long-term remitted cushing’s disease |
| title_sort | cortical thickness abnormalities in long term remitted cushing s disease |
| topic | Neuroimaging Cushing’s Disease endocrinology Psychiatric symptomatology |
| url | https://www.cambridge.org/core/product/identifier/S0924933821003631/type/journal_article |
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