Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children
The human intestinal microbiota has been shown to be modulated during inflammatory conditions. Probiotic administration has been shown to affect the immune system and cytokine expression which can affect inflammation and health outcomes. There seems to be an association between the mother's int...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.889040/full |
| _version_ | 1818469858674737152 |
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| author | Kah Onn Kwok Kah Onn Kwok Lisa R. Fries Irma Silva-Zolezzi Sagar K. Thakkar Alison Iroz Carine Blanchard |
| author_facet | Kah Onn Kwok Kah Onn Kwok Lisa R. Fries Irma Silva-Zolezzi Sagar K. Thakkar Alison Iroz Carine Blanchard |
| author_sort | Kah Onn Kwok |
| collection | DOAJ |
| description | The human intestinal microbiota has been shown to be modulated during inflammatory conditions. Probiotic administration has been shown to affect the immune system and cytokine expression which can affect inflammation and health outcomes. There seems to be an association between the mother's intestinal microbiota and inflammation biomarkers, both of which may contribute to newborn early life immune and metabolic programming and impact short and long-term health outcomes. Probiotic supplementation during pregnancy has been shown to influence metabolic health, immunity, and gastrointestinal health of the mother, and can also have carry-over benefits to infants such as infant allergy risk reduction. Therefore, this review focuses on the evidence of probiotic administration in women of reproductive age, including during pregnancy and its impact on inflammatory markers and on maternal and infant health. We performed a PubMed search for articles published in English in the last 20 years. Immune markers were narrowed to serum and breast milk levels of TNF-α, IL-6 and TGF-β, IgA, and IL-10. Studies that investigated the beneficial effects of interventions in women with gestational diabetes mellitus, polycystic ovarian syndrome, and infant allergy management are summarized. These results show a beneficial or neutral effect on selected health outcomes and that it is safe for woman and their infants. The effect of probiotics on modulation of inflammatory markers was probiotic specific. More research is needed to further our understanding of the mechanisms underlying the effects of probiotics on inflammation and how these effects improve health outcomes. |
| first_indexed | 2024-04-13T21:30:12Z |
| format | Article |
| id | doaj.art-f6dc689986e04a92b39ded704c495a69 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T21:30:12Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-f6dc689986e04a92b39ded704c495a692022-12-22T02:29:12ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-06-01910.3389/fnut.2022.889040889040Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their ChildrenKah Onn Kwok0Kah Onn Kwok1Lisa R. Fries2Irma Silva-Zolezzi3Sagar K. Thakkar4Alison Iroz5Carine Blanchard6Food Science and Technology Programme, National University of Singapore, Singapore, SingaporeNestlé Research, Singapore, SingaporeNestlé Research, Beijing, ChinaNestlé Research, Singapore, SingaporeNestlé Research, Singapore, SingaporeNestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Lausanne, SwitzerlandNestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Lausanne, SwitzerlandThe human intestinal microbiota has been shown to be modulated during inflammatory conditions. Probiotic administration has been shown to affect the immune system and cytokine expression which can affect inflammation and health outcomes. There seems to be an association between the mother's intestinal microbiota and inflammation biomarkers, both of which may contribute to newborn early life immune and metabolic programming and impact short and long-term health outcomes. Probiotic supplementation during pregnancy has been shown to influence metabolic health, immunity, and gastrointestinal health of the mother, and can also have carry-over benefits to infants such as infant allergy risk reduction. Therefore, this review focuses on the evidence of probiotic administration in women of reproductive age, including during pregnancy and its impact on inflammatory markers and on maternal and infant health. We performed a PubMed search for articles published in English in the last 20 years. Immune markers were narrowed to serum and breast milk levels of TNF-α, IL-6 and TGF-β, IgA, and IL-10. Studies that investigated the beneficial effects of interventions in women with gestational diabetes mellitus, polycystic ovarian syndrome, and infant allergy management are summarized. These results show a beneficial or neutral effect on selected health outcomes and that it is safe for woman and their infants. The effect of probiotics on modulation of inflammatory markers was probiotic specific. More research is needed to further our understanding of the mechanisms underlying the effects of probiotics on inflammation and how these effects improve health outcomes.https://www.frontiersin.org/articles/10.3389/fnut.2022.889040/fullprobioticsinflammatory markersgestational diabetespolycystic ovarian syndrome (PCOS)gestational diabetes (GDM)atopic dermatitis (AD) |
| spellingShingle | Kah Onn Kwok Kah Onn Kwok Lisa R. Fries Irma Silva-Zolezzi Sagar K. Thakkar Alison Iroz Carine Blanchard Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children Frontiers in Nutrition probiotics inflammatory markers gestational diabetes polycystic ovarian syndrome (PCOS) gestational diabetes (GDM) atopic dermatitis (AD) |
| title | Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children |
| title_full | Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children |
| title_fullStr | Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children |
| title_full_unstemmed | Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children |
| title_short | Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children |
| title_sort | effects of probiotic intervention on markers of inflammation and health outcomes in women of reproductive age and their children |
| topic | probiotics inflammatory markers gestational diabetes polycystic ovarian syndrome (PCOS) gestational diabetes (GDM) atopic dermatitis (AD) |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.889040/full |
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