Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i>
Six new sesquiterpene coumarin ethers, namely turcicanol A (<b>1</b>), turcicanol A acetate (<b>2</b>), turcicanol B (<b>3</b>), turcica ketone (<b>4</b>), 11′-dehydrokaratavicinol (<b>5</b>), and galbanaldehyde (<b>6</b>), and...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5733 |
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| author | Fatma Memnune Eruçar Sarath P. D. Senadeera Jennifer A. Wilson Ekaterina Goncharova John A. Beutler Mahmut Miski |
| author_facet | Fatma Memnune Eruçar Sarath P. D. Senadeera Jennifer A. Wilson Ekaterina Goncharova John A. Beutler Mahmut Miski |
| author_sort | Fatma Memnune Eruçar |
| collection | DOAJ |
| description | Six new sesquiterpene coumarin ethers, namely turcicanol A (<b>1</b>), turcicanol A acetate (<b>2</b>), turcicanol B (<b>3</b>), turcica ketone (<b>4</b>), 11′-dehydrokaratavicinol (<b>5</b>), and galbanaldehyde (<b>6</b>), and one new sulfur-containing compound, namely turcicasulphide (<b>7</b>), along with thirty-two known secondary metabolites were isolated from the root of the endemic species <i>Ferula turcica</i> Akalın, Miski, & Tuncay through a bioassay-guided isolation approach. The structures of the new compounds were elucidated by spectroscopic analysis and comparison with the literature. Cell growth inhibition of colon cancer cell lines (COLO205 and HCT116) and kidney cancer cell lines (UO31 and A498) was used to guide isolation. Seventeen of the compounds showed significant activity against the cell lines. |
| first_indexed | 2024-03-11T00:22:00Z |
| format | Article |
| id | doaj.art-f6dd8e3ab2e648dfbc88abe91812dced |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:22:00Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f6dd8e3ab2e648dfbc88abe91812dced2023-11-18T23:18:10ZengMDPI AGMolecules1420-30492023-07-012815573310.3390/molecules28155733Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i>Fatma Memnune Eruçar0Sarath P. D. Senadeera1Jennifer A. Wilson2Ekaterina Goncharova3John A. Beutler4Mahmut Miski5Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, TürkiyeMolecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USAMolecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USAMolecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USAMolecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USADepartment of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, TürkiyeSix new sesquiterpene coumarin ethers, namely turcicanol A (<b>1</b>), turcicanol A acetate (<b>2</b>), turcicanol B (<b>3</b>), turcica ketone (<b>4</b>), 11′-dehydrokaratavicinol (<b>5</b>), and galbanaldehyde (<b>6</b>), and one new sulfur-containing compound, namely turcicasulphide (<b>7</b>), along with thirty-two known secondary metabolites were isolated from the root of the endemic species <i>Ferula turcica</i> Akalın, Miski, & Tuncay through a bioassay-guided isolation approach. The structures of the new compounds were elucidated by spectroscopic analysis and comparison with the literature. Cell growth inhibition of colon cancer cell lines (COLO205 and HCT116) and kidney cancer cell lines (UO31 and A498) was used to guide isolation. Seventeen of the compounds showed significant activity against the cell lines.https://www.mdpi.com/1420-3049/28/15/5733Apiaceae<i>Ferula turcica</i>sesquiterpene coumarin etherssulfur-containing compoundscytotoxic activitycolon cancer |
| spellingShingle | Fatma Memnune Eruçar Sarath P. D. Senadeera Jennifer A. Wilson Ekaterina Goncharova John A. Beutler Mahmut Miski Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i> Molecules Apiaceae <i>Ferula turcica</i> sesquiterpene coumarin ethers sulfur-containing compounds cytotoxic activity colon cancer |
| title | Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i> |
| title_full | Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i> |
| title_fullStr | Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i> |
| title_full_unstemmed | Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i> |
| title_short | Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of <i>Ferula turcica</i> |
| title_sort | novel cytotoxic sesquiterpene coumarin ethers and sulfur containing compounds from the roots of i ferula turcica i |
| topic | Apiaceae <i>Ferula turcica</i> sesquiterpene coumarin ethers sulfur-containing compounds cytotoxic activity colon cancer |
| url | https://www.mdpi.com/1420-3049/28/15/5733 |
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