Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy

The increasing use of target therapy and immunocheckpoint inhibitors in cancers has brought new hope of survival to patients with advanced tumors. However, more and more adverse side-effects and toxicities of these medications had been reported, affect almost all human organs including the eye. Thes...

Full description

Bibliographic Details
Main Authors: Xiaowei LIU, Zheng WANG, Chan ZHAO, Hanping WANG, Xiaoxiao GUO, Jiaxin ZHOU, Lian DUAN, Xiaoyan SI, Li ZHANG, Yue LI, Mengzhao WANG, Juhong SHI, Meifen ZHANG
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2019-10-01
Series:Chinese Journal of Lung Cancer
Subjects:
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.09
_version_ 1819152751126380544
author Xiaowei LIU
Zheng WANG
Chan ZHAO
Hanping WANG
Xiaoxiao GUO
Jiaxin ZHOU
Lian DUAN
Xiaoyan SI
Li ZHANG
Yue LI
Mengzhao WANG
Juhong SHI
Meifen ZHANG
Li ZHANG
author_facet Xiaowei LIU
Zheng WANG
Chan ZHAO
Hanping WANG
Xiaoxiao GUO
Jiaxin ZHOU
Lian DUAN
Xiaoyan SI
Li ZHANG
Yue LI
Mengzhao WANG
Juhong SHI
Meifen ZHANG
Li ZHANG
author_sort Xiaowei LIU
collection DOAJ
description The increasing use of target therapy and immunocheckpoint inhibitors in cancers has brought new hope of survival to patients with advanced tumors. However, more and more adverse side-effects and toxicities of these medications had been reported, affect almost all human organs including the eye. These adverse effects may affect the entire ocular tissues, like eyelid, eye lashes, conjunctiva, cornea, uvea, retina, optic nerve and so on, which are always been ignored by patients and doctors. In this paper we will summarize the characteristics of the related ocular diseases and give our advice on how to diagnose and manage these diseases.
first_indexed 2024-12-22T14:54:16Z
format Article
id doaj.art-f6df4ba394bd464db5f749e6d7fd8c87
institution Directory Open Access Journal
issn 1009-3419
1999-6187
language zho
last_indexed 2024-12-22T14:54:16Z
publishDate 2019-10-01
publisher Chinese Anti-Cancer Association; Chinese Antituberculosis Association
record_format Article
series Chinese Journal of Lung Cancer
spelling doaj.art-f6df4ba394bd464db5f749e6d7fd8c872022-12-21T18:22:15ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872019-10-01221065366010.3779/j.issn.1009-3419.2019.10.09Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor TherapyXiaowei LIU0Zheng WANG1Chan ZHAO2Hanping WANG3Xiaoxiao GUO4Jiaxin ZHOU5Lian DUAN6Xiaoyan SI7Li ZHANG8Yue LI9Mengzhao WANG10Juhong SHI11Meifen ZHANG12Li ZHANG13Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Ophthalmology, Beijing Hospital, Beijing 100730, ChinaDepartment of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaThe increasing use of target therapy and immunocheckpoint inhibitors in cancers has brought new hope of survival to patients with advanced tumors. However, more and more adverse side-effects and toxicities of these medications had been reported, affect almost all human organs including the eye. These adverse effects may affect the entire ocular tissues, like eyelid, eye lashes, conjunctiva, cornea, uvea, retina, optic nerve and so on, which are always been ignored by patients and doctors. In this paper we will summarize the characteristics of the related ocular diseases and give our advice on how to diagnose and manage these diseases.http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.09Target therapyImmune checkpoint inhibitorImmunotherapy-related toxicitiesOcular diseses
spellingShingle Xiaowei LIU
Zheng WANG
Chan ZHAO
Hanping WANG
Xiaoxiao GUO
Jiaxin ZHOU
Lian DUAN
Xiaoyan SI
Li ZHANG
Yue LI
Mengzhao WANG
Juhong SHI
Meifen ZHANG
Li ZHANG
Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy
Chinese Journal of Lung Cancer
Target therapy
Immune checkpoint inhibitor
Immunotherapy-related toxicities
Ocular diseses
title Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy
title_full Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy
title_fullStr Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy
title_full_unstemmed Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy
title_short Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy
title_sort clinical diagnosis and treatment recommendations for ocular toxicities of target therapy and immune checkpoint inhibitor therapy
topic Target therapy
Immune checkpoint inhibitor
Immunotherapy-related toxicities
Ocular diseses
url http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.09
work_keys_str_mv AT xiaoweiliu clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT zhengwang clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT chanzhao clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT hanpingwang clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT xiaoxiaoguo clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT jiaxinzhou clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT lianduan clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT xiaoyansi clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT lizhang clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT yueli clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT mengzhaowang clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT juhongshi clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT meifenzhang clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy
AT lizhang clinicaldiagnosisandtreatmentrecommendationsforoculartoxicitiesoftargettherapyandimmunecheckpointinhibitortherapy