Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case report
Monkeypox, a member of the Orthopoxvirus genu, has been the center of global attention since it has been declared a public health emergency by the World Health Organization. Typically, it is a self-limiting disease; however, it can occasionally have severe presentations in patients with underlying c...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250922002542 |
| _version_ | 1811179037957029888 |
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| author | Aysswarya Manoharan Beatriz X. Braz Andrew McBride Salma Hernandez Monica Balfour Tanya Quiroz Alexis Powell Allan Rodriguez Stephen Morris Jose A. Gonzales-Zamora |
| author_facet | Aysswarya Manoharan Beatriz X. Braz Andrew McBride Salma Hernandez Monica Balfour Tanya Quiroz Alexis Powell Allan Rodriguez Stephen Morris Jose A. Gonzales-Zamora |
| author_sort | Aysswarya Manoharan |
| collection | DOAJ |
| description | Monkeypox, a member of the Orthopoxvirus genu, has been the center of global attention since it has been declared a public health emergency by the World Health Organization. Typically, it is a self-limiting disease; however, it can occasionally have severe presentations in patients with underlying conditions, such as HIV, malignancy, and transplantation. In this article, we will present a case of an immunocompetent patient with a severe presentation of monkeypox. The patient presented with facial pustules with superimposed bacterial infection; furthermore, he had painful vesicles in oral and nasal mucosa and the penis. Dermatologic conditions such as atopic dermatitis has been associated with severe monkeypox. While our patient does not have a history of atopic dermatitis, he does report contact dermatitis as well as a history of skin infections. Researchers have hypothesized that disruption of the skin barrier allows for proliferation of the monkeypox virus; therefore, it is important to take a thorough history of the patient’s skin conditions. Lastly, we described the use of Tecovirimat in our patient. Although it is impossible to demonstrate the efficacy of this medication without a randomized clinical trial, our patient seemed to have a faster improvement of the lesions after initiating this antiviral. |
| first_indexed | 2024-04-11T06:28:58Z |
| format | Article |
| id | doaj.art-f6e6bdef7cb64a438edcd80d5543d41e |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-04-11T06:28:58Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-f6e6bdef7cb64a438edcd80d5543d41e2022-12-22T04:40:17ZengElsevierIDCases2214-25092022-01-0130e01626Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case reportAysswarya Manoharan0Beatriz X. Braz1Andrew McBride2Salma Hernandez3Monica Balfour4Tanya Quiroz5Alexis Powell6Allan Rodriguez7Stephen Morris8Jose A. Gonzales-Zamora9University of Miami, Miller School of Medicine, Miami, Fl 33136, USAUniversidade Federal do Ceara, CE, BrazilUniversity of Miami, Miller School of Medicine, Miami, Fl 33136, USA; Jackson Health System. Miami, Fl 33136, USAJackson Health System. Miami, Fl 33136, USAJackson Health System. Miami, Fl 33136, USAJackson Health System. Miami, Fl 33136, USAInfectious Disease Division, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USAInfectious Disease Division, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USAInfectious Disease Division, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USAInfectious Disease Division, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Peruvian American Medical Society (PAMS), Albuquerque, NM 87111, USA; Correspondence to: 1120 NW 14th St Suite 863b, Miami, FL 33136, USA.Monkeypox, a member of the Orthopoxvirus genu, has been the center of global attention since it has been declared a public health emergency by the World Health Organization. Typically, it is a self-limiting disease; however, it can occasionally have severe presentations in patients with underlying conditions, such as HIV, malignancy, and transplantation. In this article, we will present a case of an immunocompetent patient with a severe presentation of monkeypox. The patient presented with facial pustules with superimposed bacterial infection; furthermore, he had painful vesicles in oral and nasal mucosa and the penis. Dermatologic conditions such as atopic dermatitis has been associated with severe monkeypox. While our patient does not have a history of atopic dermatitis, he does report contact dermatitis as well as a history of skin infections. Researchers have hypothesized that disruption of the skin barrier allows for proliferation of the monkeypox virus; therefore, it is important to take a thorough history of the patient’s skin conditions. Lastly, we described the use of Tecovirimat in our patient. Although it is impossible to demonstrate the efficacy of this medication without a randomized clinical trial, our patient seemed to have a faster improvement of the lesions after initiating this antiviral.http://www.sciencedirect.com/science/article/pii/S2214250922002542MonkeypoxOrthopoxvirusExanthemaBacterial infectionSevere |
| spellingShingle | Aysswarya Manoharan Beatriz X. Braz Andrew McBride Salma Hernandez Monica Balfour Tanya Quiroz Alexis Powell Allan Rodriguez Stephen Morris Jose A. Gonzales-Zamora Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case report IDCases Monkeypox Orthopoxvirus Exanthema Bacterial infection Severe |
| title | Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case report |
| title_full | Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case report |
| title_fullStr | Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case report |
| title_full_unstemmed | Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case report |
| title_short | Severe monkeypox with superimposed bacterial infection in an immunocompetent patient: A case report |
| title_sort | severe monkeypox with superimposed bacterial infection in an immunocompetent patient a case report |
| topic | Monkeypox Orthopoxvirus Exanthema Bacterial infection Severe |
| url | http://www.sciencedirect.com/science/article/pii/S2214250922002542 |
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