Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis
Mycosis fungoides is a form of cutaneous T-cell lymphoma (CTCL). Malignant CD4+ T cells have been found to adopt the T-regulatory (Treg) cell phenotype and function. We present the case of a 66-year-old man diagnosed with mycosis fungoides that was progressing from the plaque to the tumor stage. The...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-09-01
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| Series: | Dermatologica Sinica |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1027811711000619 |
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| author | Tzu-Chun Lin Po-Yuan Wu Tze-Yi Lin Su-Peng Yeh Shyh-chang Chen Tsong-Liang Lee |
| author_facet | Tzu-Chun Lin Po-Yuan Wu Tze-Yi Lin Su-Peng Yeh Shyh-chang Chen Tsong-Liang Lee |
| author_sort | Tzu-Chun Lin |
| collection | DOAJ |
| description | Mycosis fungoides is a form of cutaneous T-cell lymphoma (CTCL). Malignant CD4+ T cells have been found to adopt the T-regulatory (Treg) cell phenotype and function. We present the case of a 66-year-old man diagnosed with mycosis fungoides that was progressing from the plaque to the tumor stage. The histopathological examinations showed that the Langerhans cell (LC) infiltration in the skin lesion of the tumor stage was greater than that in the patch/plaque stage; the tumor stage lesions resembled LC histiocytosis pathologically. The associations among LCs, apoptotic tumor cells, Treg CTCL cells, and relevant cytokines are complex. Treg CTCL cells produce the immunosuppressive cytokines interleukin-10 and transforming growth factor beta, which facilitate continuous recruitment of LCs and maintenance of long-term dendritic cell immaturity, thereby explaining the remarkable LC infiltration in the tumor stage samples from our patient. This phenomenon indicates that LCs accompanied by Treg CTCL cells may play an important synergistic role in the tumor progression. The development of immunotherapy directed against Treg CTCL cells and LCs overproduction and other immunosuppressive cytokines may be a potent useful adjuvant and worthy of further investigation. |
| first_indexed | 2024-12-16T09:12:43Z |
| format | Article |
| id | doaj.art-f6e8061283e14a6c85035a06a2866b1a |
| institution | Directory Open Access Journal |
| issn | 1027-8117 |
| language | English |
| last_indexed | 2024-12-16T09:12:43Z |
| publishDate | 2011-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-f6e8061283e14a6c85035a06a2866b1a2022-12-21T22:36:58ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172011-09-0129310110510.1016/j.dsi.2011.07.006Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosisTzu-Chun Lin0Po-Yuan Wu1Tze-Yi Lin2Su-Peng Yeh3Shyh-chang Chen4Tsong-Liang Lee5Department of Dermatology, China Medical University and Hospital, Taichung, TaiwanDepartment of Dermatology, China Medical University and Hospital, Taichung, TaiwanDepartment of Pathology, China Medical University and Hospital, Taichung, TaiwanDepartment of Hematology and Oncology, China Medical University and Hospital, Taichung, TaiwanDepartment of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Dermatology, China Medical University and Hospital, Taichung, TaiwanMycosis fungoides is a form of cutaneous T-cell lymphoma (CTCL). Malignant CD4+ T cells have been found to adopt the T-regulatory (Treg) cell phenotype and function. We present the case of a 66-year-old man diagnosed with mycosis fungoides that was progressing from the plaque to the tumor stage. The histopathological examinations showed that the Langerhans cell (LC) infiltration in the skin lesion of the tumor stage was greater than that in the patch/plaque stage; the tumor stage lesions resembled LC histiocytosis pathologically. The associations among LCs, apoptotic tumor cells, Treg CTCL cells, and relevant cytokines are complex. Treg CTCL cells produce the immunosuppressive cytokines interleukin-10 and transforming growth factor beta, which facilitate continuous recruitment of LCs and maintenance of long-term dendritic cell immaturity, thereby explaining the remarkable LC infiltration in the tumor stage samples from our patient. This phenomenon indicates that LCs accompanied by Treg CTCL cells may play an important synergistic role in the tumor progression. The development of immunotherapy directed against Treg CTCL cells and LCs overproduction and other immunosuppressive cytokines may be a potent useful adjuvant and worthy of further investigation.http://www.sciencedirect.com/science/article/pii/S1027811711000619Cutaneous T-cell lymphomaLangerhans cell histiocytosisMycosis fungoidesT-regulatory cellTumor stage |
| spellingShingle | Tzu-Chun Lin Po-Yuan Wu Tze-Yi Lin Su-Peng Yeh Shyh-chang Chen Tsong-Liang Lee Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis Dermatologica Sinica Cutaneous T-cell lymphoma Langerhans cell histiocytosis Mycosis fungoides T-regulatory cell Tumor stage |
| title | Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis |
| title_full | Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis |
| title_fullStr | Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis |
| title_full_unstemmed | Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis |
| title_short | Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis |
| title_sort | langerhans cell hyperplasia in the tumor stage of mycosis fungoides a mimic of langerhans cell histiocytosis |
| topic | Cutaneous T-cell lymphoma Langerhans cell histiocytosis Mycosis fungoides T-regulatory cell Tumor stage |
| url | http://www.sciencedirect.com/science/article/pii/S1027811711000619 |
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