A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic Tweezers
Low-abundance biomolecule detection is very crucial in many biological and medical applications. In this paper, we present a novel electrolyte-gated graphene field-effect transistor (EGFET) biosensor consisting of acoustic tweezers to increase the sensitivity. The acoustic tweezers are based on a hi...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/10/1238 |
| _version_ | 1797513865018212352 |
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| author | Yan Chen Wenpeng Liu Hao Zhang Daihua Zhang Xiaoliang Guo |
| author_facet | Yan Chen Wenpeng Liu Hao Zhang Daihua Zhang Xiaoliang Guo |
| author_sort | Yan Chen |
| collection | DOAJ |
| description | Low-abundance biomolecule detection is very crucial in many biological and medical applications. In this paper, we present a novel electrolyte-gated graphene field-effect transistor (EGFET) biosensor consisting of acoustic tweezers to increase the sensitivity. The acoustic tweezers are based on a high-frequency bulk acoustic resonator with thousands of MHz, which has excellent ability to concentrate nanoparticles. The operating principle of the acoustic tweezers to concentrate biomolecules is analyzed and verified by experiments. After the actuation of acoustic tweezers for 10 min, the IgG molecules are accumulated onto the graphene. The sensitivities of the EGFET biosensor with accumulation and without accumulation are compared. As a result, the sensitivity of the graphene-based biosensor is remarkably increased using SMR as the biomolecule concentrator. Since the device has advantages such as miniaturized size, low reagent consumption, high sensitivity, and rapid detection, we expect it to be readily applied to many biological and medical applications. |
| first_indexed | 2024-03-10T06:22:36Z |
| format | Article |
| id | doaj.art-f6eb715fb8634548817976679e6ccb05 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T06:22:36Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-f6eb715fb8634548817976679e6ccb052023-11-22T19:12:03ZengMDPI AGMicromachines2072-666X2021-10-011210123810.3390/mi12101238A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic TweezersYan Chen0Wenpeng Liu1Hao Zhang2Daihua Zhang3Xiaoliang Guo4Beijing Engineering Research Center of Industrial Spectrum Imaging, School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing 100083, ChinaCollege of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaCollege of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaCollege of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaCollege of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaLow-abundance biomolecule detection is very crucial in many biological and medical applications. In this paper, we present a novel electrolyte-gated graphene field-effect transistor (EGFET) biosensor consisting of acoustic tweezers to increase the sensitivity. The acoustic tweezers are based on a high-frequency bulk acoustic resonator with thousands of MHz, which has excellent ability to concentrate nanoparticles. The operating principle of the acoustic tweezers to concentrate biomolecules is analyzed and verified by experiments. After the actuation of acoustic tweezers for 10 min, the IgG molecules are accumulated onto the graphene. The sensitivities of the EGFET biosensor with accumulation and without accumulation are compared. As a result, the sensitivity of the graphene-based biosensor is remarkably increased using SMR as the biomolecule concentrator. Since the device has advantages such as miniaturized size, low reagent consumption, high sensitivity, and rapid detection, we expect it to be readily applied to many biological and medical applications.https://www.mdpi.com/2072-666X/12/10/1238electrolyte-gated graphene field-effect transistorsacoustic tweezerssolid mounted resonator (SMR) |
| spellingShingle | Yan Chen Wenpeng Liu Hao Zhang Daihua Zhang Xiaoliang Guo A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic Tweezers Micromachines electrolyte-gated graphene field-effect transistors acoustic tweezers solid mounted resonator (SMR) |
| title | A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic Tweezers |
| title_full | A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic Tweezers |
| title_fullStr | A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic Tweezers |
| title_full_unstemmed | A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic Tweezers |
| title_short | A Sensitivity-Enhanced Electrolyte-Gated Graphene Field-Effect Transistor Biosensor by Acoustic Tweezers |
| title_sort | sensitivity enhanced electrolyte gated graphene field effect transistor biosensor by acoustic tweezers |
| topic | electrolyte-gated graphene field-effect transistors acoustic tweezers solid mounted resonator (SMR) |
| url | https://www.mdpi.com/2072-666X/12/10/1238 |
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