Characterizing the Mechanism of Action of an Ancient Antimicrobial, Manuka Honey, against Pseudomonas aeruginosa Using Modern Transcriptomics

Characterizing the Mechanism of Action of an Ancient Antimicrobial, Manuka Honey, against Pseudomonas aeruginosa Using Modern Transcriptomics

ABSTRACT Manuka honey has broad-spectrum antimicrobial activity, and unlike traditional antibiotics, resistance to its killing effects has not been reported. However, its mechanism of action remains unclear. Here, we investigated the mechanism of action of manuka honey and its key antibacterial comp...

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Bibliographic Details
Main Authors: Daniel Bouzo, Nural N. Cokcetin, Liping Li, Giulia Ballerin, Amy L. Bottomley, James Lazenby, Cynthia B. Whitchurch, Ian T. Paulsen, Karl A. Hassan, Elizabeth J. Harry
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSystems
Subjects:
Pseudomonas aeruginosa
RNA-Seq
antimicrobial activity
honey
manuka honey
mechanism of action
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00106-20

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