Efficacy and Safety of Controlled Ovarian Stimulation With or Without Letrozole Co-administration for Fertility Preservation: A Systematic Review and Meta-Analysis

Efficacy and Safety of Controlled Ovarian Stimulation With or Without Letrozole Co-administration for Fertility Preservation: A Systematic Review and Meta-Analysis

Background: The co-administration of letrozole during controlled ovarian stimulation (COS) with gonadotropins is used to limit the potentially harmful effects of a supra-physiological rise in estrogen levels on hormone-sensitive cancers. However, the efficacy and safety of adding letrozole to COS re...

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Bibliographic Details
Main Authors: Benedetta Bonardi, Claudia Massarotti, Marco Bruzzone, Oranite Goldrat, Giorgia Mangili, Paola Anserini, Stefano Spinaci, Luca Arecco, Lucia Del Mastro, Marcello Ceppi, Isabelle Demeestere, Matteo Lambertini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
fertility
controlled ovarian stimulation
letrozole
gonadotropins
breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.574669/full

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