Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation
This paper aimed to examine the impact of flavonoid osajin (OSJ) on liver damage induced by sepsis. A total of 30 male rats were divided into 5 groups (Sham, sepsis, OSJ 150, OSJ 300 and reference). During sepsis, elevated lipid peroxidation (LPO) level and catalase activity (CAT) and decreased glut...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Taibah University for Science |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16583655.2023.2201250 |
| _version_ | 1797215197453090816 |
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| author | Mohammad Alhilal Huseyin Serkan Erol Serkan Yildirim Ahmet Cakir Murat Koc Demet Celebi Mesut Bunyami Halici |
| author_facet | Mohammad Alhilal Huseyin Serkan Erol Serkan Yildirim Ahmet Cakir Murat Koc Demet Celebi Mesut Bunyami Halici |
| author_sort | Mohammad Alhilal |
| collection | DOAJ |
| description | This paper aimed to examine the impact of flavonoid osajin (OSJ) on liver damage induced by sepsis. A total of 30 male rats were divided into 5 groups (Sham, sepsis, OSJ 150, OSJ 300 and reference). During sepsis, elevated lipid peroxidation (LPO) level and catalase activity (CAT) and decreased glutathione (GSH) level and superoxide dismutase (SOD) activity were observed in hepatic tissues of sepsis group in comparison with Sham group. A strong interleukin-33 and caspase-3 expressions were detected in hepatic tissues of sepsis group. On the contrary, OSJ administration to OSJ 300 group showed a significant decrease (P < 0.001) in LPO level (176±2.926) and significant increase (P < 0.001) in GSH level (10.586±0.083) and SOD activity (29.152±0.094) in comparison with sepsis group (185.777±1.735, 8.246±0.124, 24.307±0.379 respectively). In addition, the consumption of OSJ reduced expressions of interleukin-33 and caspase-3 and improved histopathological integrity. In conclusions, OSJ has hepatoprotective effect against sepsis-induced liver injury. |
| first_indexed | 2024-03-10T08:14:14Z |
| format | Article |
| id | doaj.art-f6ed80b67f304cfe89eb3ae4d424470a |
| institution | Directory Open Access Journal |
| issn | 1658-3655 |
| language | English |
| last_indexed | 2024-04-24T11:26:14Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj.art-f6ed80b67f304cfe89eb3ae4d424470a2024-04-10T20:17:48ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552023-12-0117110.1080/16583655.2023.2201250Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimationMohammad Alhilal0Huseyin Serkan Erol1Serkan Yildirim2Ahmet Cakir3Murat Koc4Demet Celebi5Mesut Bunyami Halici6Department of Nursing, Faculty of Health Sciences, Mardin Artuklu University, Mardin, TurkeyDepartment of Biochemistry, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu, TurkeyDepartment of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, TurkeyDepartment of Chemistry, Faculty of Arts and Sciences, Kilis 7 Aralık University, Kilis, TurkeyDepartment of Tradational, Complementary and Integrative Medicine, Public Health Institute, Ankara Yildirim Beyazit University, Ankara, TurkeyDepartment of Microbiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, TurkeyDepartment of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, TurkeyThis paper aimed to examine the impact of flavonoid osajin (OSJ) on liver damage induced by sepsis. A total of 30 male rats were divided into 5 groups (Sham, sepsis, OSJ 150, OSJ 300 and reference). During sepsis, elevated lipid peroxidation (LPO) level and catalase activity (CAT) and decreased glutathione (GSH) level and superoxide dismutase (SOD) activity were observed in hepatic tissues of sepsis group in comparison with Sham group. A strong interleukin-33 and caspase-3 expressions were detected in hepatic tissues of sepsis group. On the contrary, OSJ administration to OSJ 300 group showed a significant decrease (P < 0.001) in LPO level (176±2.926) and significant increase (P < 0.001) in GSH level (10.586±0.083) and SOD activity (29.152±0.094) in comparison with sepsis group (185.777±1.735, 8.246±0.124, 24.307±0.379 respectively). In addition, the consumption of OSJ reduced expressions of interleukin-33 and caspase-3 and improved histopathological integrity. In conclusions, OSJ has hepatoprotective effect against sepsis-induced liver injury.https://www.tandfonline.com/doi/10.1080/16583655.2023.2201250Liverosajinoxidative stresssepsis |
| spellingShingle | Mohammad Alhilal Huseyin Serkan Erol Serkan Yildirim Ahmet Cakir Murat Koc Demet Celebi Mesut Bunyami Halici Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation Journal of Taibah University for Science Liver osajin oxidative stress sepsis |
| title | Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation |
| title_full | Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation |
| title_fullStr | Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation |
| title_full_unstemmed | Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation |
| title_short | Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation |
| title_sort | osajin from maclura pomifera alleviates sepsis induced liver injury in rats biochemical histopathological and immunohistochemical estimation |
| topic | Liver osajin oxidative stress sepsis |
| url | https://www.tandfonline.com/doi/10.1080/16583655.2023.2201250 |
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