The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis
A number of bacteria that colonize the human body produce toxins and effectors that cause changes in the eukaryotic cell cycle—cyclomodulins and low-molecular-weight compounds such as butyrate, lactic acid, and secondary bile acids. Cyclomodulins and metabolites are necessary for bacteria as adaptat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11706 |
| _version_ | 1797478942111694848 |
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| author | Natalia N. Markelova Elena F. Semenova Olga N. Sineva Vera S. Sadykova |
| author_facet | Natalia N. Markelova Elena F. Semenova Olga N. Sineva Vera S. Sadykova |
| author_sort | Natalia N. Markelova |
| collection | DOAJ |
| description | A number of bacteria that colonize the human body produce toxins and effectors that cause changes in the eukaryotic cell cycle—cyclomodulins and low-molecular-weight compounds such as butyrate, lactic acid, and secondary bile acids. Cyclomodulins and metabolites are necessary for bacteria as adaptation factors—which are influenced by direct selection—to the ecological niches of the host. In the process of establishing two-way communication with the macroorganism, these compounds cause limited damage to the host, despite their ability to disrupt key processes in eukaryotic cells, which can lead to pathological changes. Possible negative consequences of cyclomodulin and metabolite actions include their potential role in carcinogenesis, in particular, with the ability to cause DNA damage, increase genome instability, and interfere with cancer-associated regulatory pathways. In this review, we aim to examine cyclomodulins and bacterial metabolites as important factors in bacterial survival and interaction with the host organism to show their heterogeneous effect on oncogenesis depending on the surrounding microenvironment, pathological conditions, and host genetic background. |
| first_indexed | 2024-03-09T21:38:47Z |
| format | Article |
| id | doaj.art-f6edf75dc6194806a59b23291b36cf1f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:38:47Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f6edf75dc6194806a59b23291b36cf1f2023-11-23T20:37:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191170610.3390/ijms231911706The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism CarcinogenesisNatalia N. Markelova0Elena F. Semenova1Olga N. Sineva2Vera S. Sadykova3Gause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaInstitute of Biochemical Technology, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, RussiaGause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaGause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaA number of bacteria that colonize the human body produce toxins and effectors that cause changes in the eukaryotic cell cycle—cyclomodulins and low-molecular-weight compounds such as butyrate, lactic acid, and secondary bile acids. Cyclomodulins and metabolites are necessary for bacteria as adaptation factors—which are influenced by direct selection—to the ecological niches of the host. In the process of establishing two-way communication with the macroorganism, these compounds cause limited damage to the host, despite their ability to disrupt key processes in eukaryotic cells, which can lead to pathological changes. Possible negative consequences of cyclomodulin and metabolite actions include their potential role in carcinogenesis, in particular, with the ability to cause DNA damage, increase genome instability, and interfere with cancer-associated regulatory pathways. In this review, we aim to examine cyclomodulins and bacterial metabolites as important factors in bacterial survival and interaction with the host organism to show their heterogeneous effect on oncogenesis depending on the surrounding microenvironment, pathological conditions, and host genetic background.https://www.mdpi.com/1422-0067/23/19/11706cyclomodulinsgenotoxinsbacterial metabolitesmicroecologycarcinogenesis |
| spellingShingle | Natalia N. Markelova Elena F. Semenova Olga N. Sineva Vera S. Sadykova The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis International Journal of Molecular Sciences cyclomodulins genotoxins bacterial metabolites microecology carcinogenesis |
| title | The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis |
| title_full | The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis |
| title_fullStr | The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis |
| title_full_unstemmed | The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis |
| title_short | The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis |
| title_sort | role of cyclomodulins and some microbial metabolites in bacterial microecology and macroorganism carcinogenesis |
| topic | cyclomodulins genotoxins bacterial metabolites microecology carcinogenesis |
| url | https://www.mdpi.com/1422-0067/23/19/11706 |
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