FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME
Fifty patients with primary "dry eye" syndrome underwent examination of systemic immunity including the determination of cell populations and subsets of CD3+, CD4+, CD8+, CD16+, CD20+ lymphocytes; measurements of major immunoglobulins: IgA, IgM, IgG; circulatory immune complexes (CIC); rhe...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/470 |
| _version_ | 1826534297773801472 |
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| author | N. N. Ratkina O. F. Lykova O. Y. Baturina O. A. Klitsenko |
| author_facet | N. N. Ratkina O. F. Lykova O. Y. Baturina O. A. Klitsenko |
| author_sort | N. N. Ratkina |
| collection | DOAJ |
| description | Fifty patients with primary "dry eye" syndrome underwent examination of systemic immunity including the determination of cell populations and subsets of CD3+, CD4+, CD8+, CD16+, CD20+ lymphocytes; measurements of major immunoglobulins: IgA, IgM, IgG; circulatory immune complexes (CIC); rheumatoid factor, antibodies to denatured and nondenatured DNA, and phagocytic index. When compared to relatively healthy subjects (n = 30), the patients, showed decreased contents of CD3+ and CD4+T-lymphocytes, increased IgM and CIC concentrations, along with presence of autoantibodies in blood. Moreover, some variable changes were revealed in the quantities of CD8+ cytotoxic T-lymphocytes, and the values of immunoregulatory index (IRI). As based on immunologic findings, with regard of CIC contents, autoantibody titers and IRI values, we have discerned four types of primary "dry eye" syndrome, i.e., simple, cytotoxic, CIC-positive, and Sjogren's syndrome. The changes of systemic immunity in the patients with different etiology of primary "dry eye" syndrome should be considered when elaborating therapeutic strategies and aiming for prophylaxis of immunologic disorders in such a cohort of patients. |
| first_indexed | 2024-03-08T05:51:14Z |
| format | Article |
| id | doaj.art-f6ee1c1247d242cab2093587203a52df |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:20:47Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-f6ee1c1247d242cab2093587203a52df2025-03-11T17:59:03ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0112654755210.15789/1563-0625-2010-6-547-552467FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROMEN. N. Ratkina0O. F. Lykova1O. Y. Baturina2O. A. Klitsenko3ГОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Росздрава, г. НовокузнецкГОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Росздрава, г. НовокузнецкКлиника «Центр глазной хирургии», г. НовокузнецкСанкт-Петербургская медицинская академия последипломного образования, Санкт-ПетербургFifty patients with primary "dry eye" syndrome underwent examination of systemic immunity including the determination of cell populations and subsets of CD3+, CD4+, CD8+, CD16+, CD20+ lymphocytes; measurements of major immunoglobulins: IgA, IgM, IgG; circulatory immune complexes (CIC); rheumatoid factor, antibodies to denatured and nondenatured DNA, and phagocytic index. When compared to relatively healthy subjects (n = 30), the patients, showed decreased contents of CD3+ and CD4+T-lymphocytes, increased IgM and CIC concentrations, along with presence of autoantibodies in blood. Moreover, some variable changes were revealed in the quantities of CD8+ cytotoxic T-lymphocytes, and the values of immunoregulatory index (IRI). As based on immunologic findings, with regard of CIC contents, autoantibody titers and IRI values, we have discerned four types of primary "dry eye" syndrome, i.e., simple, cytotoxic, CIC-positive, and Sjogren's syndrome. The changes of systemic immunity in the patients with different etiology of primary "dry eye" syndrome should be considered when elaborating therapeutic strategies and aiming for prophylaxis of immunologic disorders in such a cohort of patients.https://www.mimmun.ru/mimmun/article/view/470primary “dry eye” syndromeimmunologic indicesclassification |
| spellingShingle | N. N. Ratkina O. F. Lykova O. Y. Baturina O. A. Klitsenko FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME Медицинская иммунология primary “dry eye” syndrome immunologic indices classification |
| title | FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME |
| title_full | FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME |
| title_fullStr | FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME |
| title_full_unstemmed | FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME |
| title_short | FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME |
| title_sort | features of systemic immunity in patients with a primary dry eye syndrome |
| topic | primary “dry eye” syndrome immunologic indices classification |
| url | https://www.mimmun.ru/mimmun/article/view/470 |
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