Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects
Abstract Direct cell-to-cell communication is crucial for the survival of cells in stressful situations such as during or after radiation exposure. This communication can lead to non-targeted effects, where non-treated or non-infected cells show effects induced by signal transduction from non-health...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-019-1416-8 |
| _version_ | 1818332217294716928 |
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| author | Nicole Matejka Judith Reindl |
| author_facet | Nicole Matejka Judith Reindl |
| author_sort | Nicole Matejka |
| collection | DOAJ |
| description | Abstract Direct cell-to-cell communication is crucial for the survival of cells in stressful situations such as during or after radiation exposure. This communication can lead to non-targeted effects, where non-treated or non-infected cells show effects induced by signal transduction from non-healthy cells or vice versa. In the last 15 years, tunneling nanotubes (TNTs) were identified as membrane connections between cells which facilitate the transfer of several cargoes and signals. TNTs were identified in various cell types and serve as promoter of treatment resistance e.g. in chemotherapy treatment of cancer. Here, we discuss our current understanding of how to differentiate tunneling nanotubes from other direct cellular connections and their role in the stress reaction of cellular networks. We also provide a perspective on how the capability of cells to form such networks is related to the ability to surpass stress and how this can be used to study radioresistance of cancer cells. |
| first_indexed | 2024-12-13T13:32:14Z |
| format | Article |
| id | doaj.art-f6ef53a80f2b494da0c711d87edb0b11 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-13T13:32:14Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-f6ef53a80f2b494da0c711d87edb0b112022-12-21T23:44:09ZengBMCRadiation Oncology1748-717X2019-12-0114111110.1186/s13014-019-1416-8Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effectsNicole Matejka0Judith Reindl1Institut für angewandte Physik und Messtechnik, Universität der Bundeswehr MünchenInstitut für angewandte Physik und Messtechnik, Universität der Bundeswehr MünchenAbstract Direct cell-to-cell communication is crucial for the survival of cells in stressful situations such as during or after radiation exposure. This communication can lead to non-targeted effects, where non-treated or non-infected cells show effects induced by signal transduction from non-healthy cells or vice versa. In the last 15 years, tunneling nanotubes (TNTs) were identified as membrane connections between cells which facilitate the transfer of several cargoes and signals. TNTs were identified in various cell types and serve as promoter of treatment resistance e.g. in chemotherapy treatment of cancer. Here, we discuss our current understanding of how to differentiate tunneling nanotubes from other direct cellular connections and their role in the stress reaction of cellular networks. We also provide a perspective on how the capability of cells to form such networks is related to the ability to surpass stress and how this can be used to study radioresistance of cancer cells.https://doi.org/10.1186/s13014-019-1416-8Cellular communicationTunneling nanotubesRadioresistanceCancer |
| spellingShingle | Nicole Matejka Judith Reindl Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects Radiation Oncology Cellular communication Tunneling nanotubes Radioresistance Cancer |
| title | Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects |
| title_full | Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects |
| title_fullStr | Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects |
| title_full_unstemmed | Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects |
| title_short | Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects |
| title_sort | perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects |
| topic | Cellular communication Tunneling nanotubes Radioresistance Cancer |
| url | https://doi.org/10.1186/s13014-019-1416-8 |
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