Toll-Like Receptor 4/Spleen Tyrosine Kinase Complex in High Glucose Signal Transduction of Proximal Tubular Epithelial Cells

Toll-Like Receptor 4/Spleen Tyrosine Kinase Complex in High Glucose Signal Transduction of Proximal Tubular Epithelial Cells

Background/Aims: High glucose activates spleen tyrosine kinase (Syk) in human proximal tubular epithelial cells (HK-2 cells), which leads to NF-κB activation and transforming growth factor-ß1 (TGF-ß1) production. We explored the signal transduction pathway from high glucose to Syk activatio...

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Bibliographic Details
Main Authors: Won Seok Yang, Joon-Seok Kim, Nam Jeong Han, Mee Jeong Lee, Su-Kil Park
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
High glucose
High-mobility group box-1
MyD88
Spleen tyrosine kinase
Toll-like receptor 4
Transforming growth factor-β1
Online Access:http://www.karger.com/Article/FullText/374034

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