Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

Abstract Background Perturbation of commensal intestinal microbiota has been associated with several autoimmune diseases. Mice deficient in interleukin-1 receptor antagonist (Il1rn −/− mice) spontaneously develop autoimmune arthritis and are susceptible to other autoimmune diseases such as psoriasis...

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Bibliographic Details
Main Authors: Rebecca Rogier, Thomas H. A. Ederveen, Jos Boekhorst, Harm Wopereis, Jose U. Scher, Julia Manasson, Sanne J. C. M. Frambach, Jan Knol, Johan Garssen, Peter M. van der Kraan, Marije I. Koenders, Wim B. van den Berg, Sacha A. F. T. van Hijum, Shahla Abdollahi-Roodsaz
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Microbiome
Subjects:
Microbiota
Autoimmune arthritis
T helper 17 cells
Toll-like receptors
IL-1 receptor antagonist
Online Access:http://link.springer.com/article/10.1186/s40168-017-0278-2

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