Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection

The present study investigated the effects of dietary conjugated linoleic acid (CLA) on the cellular immune response of piglets after cyclosporin A (CsA) treatment. The experimental study had a 2×2 factorial design, and the main factors consisted of diets (0% or 2% CLA) and immunosuppression treatme...

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Main Authors: Y.X. Liu, K.Y. Zhu, Y.L. Liu, D.F. Jiang
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Animal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1751731116000604
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author Y.X. Liu
K.Y. Zhu
Y.L. Liu
D.F. Jiang
author_facet Y.X. Liu
K.Y. Zhu
Y.L. Liu
D.F. Jiang
author_sort Y.X. Liu
collection DOAJ
description The present study investigated the effects of dietary conjugated linoleic acid (CLA) on the cellular immune response of piglets after cyclosporin A (CsA) treatment. The experimental study had a 2×2 factorial design, and the main factors consisted of diets (0% or 2% CLA) and immunosuppression treatments (CsA or saline injection). CsA injection significantly increased feed : gain (F : G) of piglets (P<0.05); however, dietary CLA significantly decreased F : G of piglets (P<0.05). Dietary CLA partly ameliorated the deterioration of the feed conversion rate caused by CsA treatment (P<0.01). CsA treatment significantly decreased the percentages of CD4+ and CD8+ T lymphocytes in the thymus (P<0.01). Dietary CLA increased the percentages of CD4+ CD8+ double-positive and CD8+ single-positive T lymphocytes in the thymus (P<0.05), and had the trend to inhibit the decrease of CD4+ T lymphocytes in the thymus after CsA injection (P=0.07). CsA treatment significantly depleted the peripheral blood CD3+, CD4+ and CD8+ T lymphocytes (P<0.01). Dietary CLA significantly increased the number of peripheral blood CD8+ T lymphocytes and interleukin-2 (IL-2) production (P<0.05), and inhibited the decreases of peripheral blood CD3+, CD4+ and CD8+ T lymphocytes counts (P<0.01) as well as IL-2 production (P<0.05) after CsA treatment. Dietary CLA partly rescued the decrease of lymphocyte proliferation after CsA injection (P<0.05). In summary, dietary CLA effectively ameliorated CsA-induced cellular immunosuppression in piglets.
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spelling doaj.art-f6f14bda090b43d49346005d9e9602a92022-12-21T22:58:43ZengElsevierAnimal1751-73112016-01-01101016601665Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injectionY.X. Liu0K.Y. Zhu1Y.L. Liu2D.F. Jiang3College of Animal Husbandry Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, P. R. ChinaCollege of Animal Husbandry Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, P. R. ChinaHenan Engineering Technology Research Center of Animal Nutrition and Feed, Zhengzhou 450046, Henan Province, P. R. ChinaHenan Engineering Technology Research Center of Animal Nutrition and Feed, Zhengzhou 450046, Henan Province, P. R. ChinaThe present study investigated the effects of dietary conjugated linoleic acid (CLA) on the cellular immune response of piglets after cyclosporin A (CsA) treatment. The experimental study had a 2×2 factorial design, and the main factors consisted of diets (0% or 2% CLA) and immunosuppression treatments (CsA or saline injection). CsA injection significantly increased feed : gain (F : G) of piglets (P<0.05); however, dietary CLA significantly decreased F : G of piglets (P<0.05). Dietary CLA partly ameliorated the deterioration of the feed conversion rate caused by CsA treatment (P<0.01). CsA treatment significantly decreased the percentages of CD4+ and CD8+ T lymphocytes in the thymus (P<0.01). Dietary CLA increased the percentages of CD4+ CD8+ double-positive and CD8+ single-positive T lymphocytes in the thymus (P<0.05), and had the trend to inhibit the decrease of CD4+ T lymphocytes in the thymus after CsA injection (P=0.07). CsA treatment significantly depleted the peripheral blood CD3+, CD4+ and CD8+ T lymphocytes (P<0.01). Dietary CLA significantly increased the number of peripheral blood CD8+ T lymphocytes and interleukin-2 (IL-2) production (P<0.05), and inhibited the decreases of peripheral blood CD3+, CD4+ and CD8+ T lymphocytes counts (P<0.01) as well as IL-2 production (P<0.05) after CsA treatment. Dietary CLA partly rescued the decrease of lymphocyte proliferation after CsA injection (P<0.05). In summary, dietary CLA effectively ameliorated CsA-induced cellular immunosuppression in piglets.http://www.sciencedirect.com/science/article/pii/S1751731116000604conjugated linoleic acidspigletcyclosporin Acellular immunity
spellingShingle Y.X. Liu
K.Y. Zhu
Y.L. Liu
D.F. Jiang
Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection
Animal
conjugated linoleic acids
piglet
cyclosporin A
cellular immunity
title Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection
title_full Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection
title_fullStr Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection
title_full_unstemmed Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection
title_short Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection
title_sort effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin a injection
topic conjugated linoleic acids
piglet
cyclosporin A
cellular immunity
url http://www.sciencedirect.com/science/article/pii/S1751731116000604
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AT ylliu effectsofdietaryconjugatedlinoleicacidsoncellularimmuneresponseofpigletsaftercyclosporinainjection
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