Endoscopic image-guided laser treatment system based on fiber bundle laser steering
Abstract A miniaturized endoscopic laser system with laser steering has great potential to expand the application of minimally invasive laser treatment for micro-lesions inside narrow organs. The conventional systems require separate optical paths for endoscopic imaging and laser steering, which lim...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29392-4 |
| _version_ | 1797865084533342208 |
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| author | Yuto Miyoshi Takahiro Nishimura Yu Shimojo Keita Okayama Kunio Awazu |
| author_facet | Yuto Miyoshi Takahiro Nishimura Yu Shimojo Keita Okayama Kunio Awazu |
| author_sort | Yuto Miyoshi |
| collection | DOAJ |
| description | Abstract A miniaturized endoscopic laser system with laser steering has great potential to expand the application of minimally invasive laser treatment for micro-lesions inside narrow organs. The conventional systems require separate optical paths for endoscopic imaging and laser steering, which limits their application inside narrower organs. Herein, we present a novel endoscopic image-guided laser treatment system with a thin tip that can access inside narrow organs. The system uses a single fiber bundle to simultaneously acquire endoscopic images and modulate the laser-irradiated area. The insertion and operation of the system in a narrow space were demonstrated using an artificial vascular model. Repeated laser steering along set targets demonstrated accurate laser irradiation within a root-mean-square error of 28 $$\mu$$ μ m, and static repeatability such that the laser irradiation position was controlled within a 12 $$\mu$$ μ m radius of dispersion about the mean trajectory. Unexpected irradiation on the distal irradiated plane due to fiber bundle crosstalk was reduced by selecting the appropriate laser input diameter. The laser steering trajectory spatially controlled the photothermal effects, vaporization, and coagulation of chicken liver tissue. This novel system achieves minimally invasive endoscopic laser treatment with high lesion-selectivity in narrow organs, such as the peripheral lung and coronary arteries. |
| first_indexed | 2024-04-09T23:03:30Z |
| format | Article |
| id | doaj.art-f6f1a759bd174db39661c9d2d104bc20 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:03:30Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f6f1a759bd174db39661c9d2d104bc202023-03-22T10:53:57ZengNature PortfolioScientific Reports2045-23222023-02-0113111010.1038/s41598-023-29392-4Endoscopic image-guided laser treatment system based on fiber bundle laser steeringYuto Miyoshi0Takahiro Nishimura1Yu Shimojo2Keita Okayama3Kunio Awazu4Graduate School of Engineering, Osaka UniversityGraduate School of Engineering, Osaka UniversityGraduate School of Engineering, Osaka UniversityGraduate School of Medicine, Osaka UniversityGraduate School of Engineering, Osaka UniversityAbstract A miniaturized endoscopic laser system with laser steering has great potential to expand the application of minimally invasive laser treatment for micro-lesions inside narrow organs. The conventional systems require separate optical paths for endoscopic imaging and laser steering, which limits their application inside narrower organs. Herein, we present a novel endoscopic image-guided laser treatment system with a thin tip that can access inside narrow organs. The system uses a single fiber bundle to simultaneously acquire endoscopic images and modulate the laser-irradiated area. The insertion and operation of the system in a narrow space were demonstrated using an artificial vascular model. Repeated laser steering along set targets demonstrated accurate laser irradiation within a root-mean-square error of 28 $$\mu$$ μ m, and static repeatability such that the laser irradiation position was controlled within a 12 $$\mu$$ μ m radius of dispersion about the mean trajectory. Unexpected irradiation on the distal irradiated plane due to fiber bundle crosstalk was reduced by selecting the appropriate laser input diameter. The laser steering trajectory spatially controlled the photothermal effects, vaporization, and coagulation of chicken liver tissue. This novel system achieves minimally invasive endoscopic laser treatment with high lesion-selectivity in narrow organs, such as the peripheral lung and coronary arteries.https://doi.org/10.1038/s41598-023-29392-4 |
| spellingShingle | Yuto Miyoshi Takahiro Nishimura Yu Shimojo Keita Okayama Kunio Awazu Endoscopic image-guided laser treatment system based on fiber bundle laser steering Scientific Reports |
| title | Endoscopic image-guided laser treatment system based on fiber bundle laser steering |
| title_full | Endoscopic image-guided laser treatment system based on fiber bundle laser steering |
| title_fullStr | Endoscopic image-guided laser treatment system based on fiber bundle laser steering |
| title_full_unstemmed | Endoscopic image-guided laser treatment system based on fiber bundle laser steering |
| title_short | Endoscopic image-guided laser treatment system based on fiber bundle laser steering |
| title_sort | endoscopic image guided laser treatment system based on fiber bundle laser steering |
| url | https://doi.org/10.1038/s41598-023-29392-4 |
| work_keys_str_mv | AT yutomiyoshi endoscopicimageguidedlasertreatmentsystembasedonfiberbundlelasersteering AT takahironishimura endoscopicimageguidedlasertreatmentsystembasedonfiberbundlelasersteering AT yushimojo endoscopicimageguidedlasertreatmentsystembasedonfiberbundlelasersteering AT keitaokayama endoscopicimageguidedlasertreatmentsystembasedonfiberbundlelasersteering AT kunioawazu endoscopicimageguidedlasertreatmentsystembasedonfiberbundlelasersteering |