Heat shock proteins and oral diseases
Heat shock proteins (HSPs) are substances expressed in response to elevated temperatures or other cellular stress. They are highly conserved proteins inhabiting nearly all subcellular compartments and are found in all organisms and all cell types. When a cell is stressed, oligomeric complexes disass...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | SRM Journal of Research in Dental Sciences |
| Subjects: | |
| Online Access: | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2012;volume=3;issue=2;spage=131;epage=134;aulast=Babu |
| _version_ | 1798004896844218368 |
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| author | G Suresh Babu K V Chalapathi M Ravikanth N Govindraj Kumar |
| author_facet | G Suresh Babu K V Chalapathi M Ravikanth N Govindraj Kumar |
| author_sort | G Suresh Babu |
| collection | DOAJ |
| description | Heat shock proteins (HSPs) are substances expressed in response to elevated temperatures or other cellular stress. They are highly conserved proteins inhabiting nearly all subcellular compartments and are found in all organisms and all cell types. When a cell is stressed, oligomeric complexes disassemble and polypeptides unfold. Under these conditions, the role of HSPs is to reverse such changes and, if refolding becomes impossible, to potentially speed up the removal of such denatured proteins. Expression of HSPs is induced even under non-stress conditions, including those of the cell cycle, development, and differentiation. As oral cavity is subjected to wide range of environmental stresses like temperature variations, exposure to noxious substances and psychological disturbances, HSP′s show immunomodulatory effects. In this article the role of HSPs expression in various microbial infections, autoimmune diseases, as well as in oral squamous cell carcinoma are expressed. |
| first_indexed | 2024-04-11T12:30:44Z |
| format | Article |
| id | doaj.art-f6f2aed754df42dcbfe8ed170726af43 |
| institution | Directory Open Access Journal |
| issn | 2772-5243 2772-5251 |
| language | English |
| last_indexed | 2024-04-11T12:30:44Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | SRM Journal of Research in Dental Sciences |
| spelling | doaj.art-f6f2aed754df42dcbfe8ed170726af432022-12-22T04:23:45ZengWolters Kluwer Medknow PublicationsSRM Journal of Research in Dental Sciences2772-52432772-52512012-01-0132131134Heat shock proteins and oral diseasesG Suresh BabuK V ChalapathiM RavikanthN Govindraj KumarHeat shock proteins (HSPs) are substances expressed in response to elevated temperatures or other cellular stress. They are highly conserved proteins inhabiting nearly all subcellular compartments and are found in all organisms and all cell types. When a cell is stressed, oligomeric complexes disassemble and polypeptides unfold. Under these conditions, the role of HSPs is to reverse such changes and, if refolding becomes impossible, to potentially speed up the removal of such denatured proteins. Expression of HSPs is induced even under non-stress conditions, including those of the cell cycle, development, and differentiation. As oral cavity is subjected to wide range of environmental stresses like temperature variations, exposure to noxious substances and psychological disturbances, HSP′s show immunomodulatory effects. In this article the role of HSPs expression in various microbial infections, autoimmune diseases, as well as in oral squamous cell carcinoma are expressed.http://www.srmjrds.in/article.asp?issn=0976-433X;year=2012;volume=3;issue=2;spage=131;epage=134;aulast=Babuheat shock proteinsheat shock factorchaperoninmolecular chaperonesconserved proteins. |
| spellingShingle | G Suresh Babu K V Chalapathi M Ravikanth N Govindraj Kumar Heat shock proteins and oral diseases SRM Journal of Research in Dental Sciences heat shock proteins heat shock factor chaperonin molecular chaperones conserved proteins. |
| title | Heat shock proteins and oral diseases |
| title_full | Heat shock proteins and oral diseases |
| title_fullStr | Heat shock proteins and oral diseases |
| title_full_unstemmed | Heat shock proteins and oral diseases |
| title_short | Heat shock proteins and oral diseases |
| title_sort | heat shock proteins and oral diseases |
| topic | heat shock proteins heat shock factor chaperonin molecular chaperones conserved proteins. |
| url | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2012;volume=3;issue=2;spage=131;epage=134;aulast=Babu |
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