Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury
Recent data of study H2S in gastrointestinal tract has proven its potent cytoprotection on mucosal defense among acid-related diseases in the gut. The aim was to evaluate the effects of H2S-releasing aspirin derivative (ATB-340) on esophageal and gastric mucosa compromised by stress injury. Rats wer...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2017-04-01
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| Series: | The Ukrainian Biochemical Journal |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2017/03/Zayachkivska_SI_01_17.pdf |
| _version_ | 1797641791207374848 |
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| author | O. S. Zayachkivska1 N. S. Bula1 Ya. I. Pavlovskiy1 I. O. Pshyk-Titko1 E. M. Gavriluk1 O. I. Grushka1 J. L. Wallace2 |
| author_facet | O. S. Zayachkivska1 N. S. Bula1 Ya. I. Pavlovskiy1 I. O. Pshyk-Titko1 E. M. Gavriluk1 O. I. Grushka1 J. L. Wallace2 |
| author_sort | O. S. Zayachkivska1 |
| collection | DOAJ |
| description | Recent data of study H2S in gastrointestinal tract has proven its potent cytoprotection on mucosal defense among acid-related diseases in the gut. The aim was to evaluate the effects of H2S-releasing aspirin derivative (ATB-340) on esophageal and gastric mucosa compromised by stress injury. Rats were treated with vehicle (control), aspirin (10 mg/kg), ATB-340 (17.5 mg/kg) single or 9 days duration, with or without induction of stress injury. Esophageal mucosa, gastric mucosa were estimated by histopathological damage scoring. Serological levels of VCAM-1, IL-6 by ELISA. ATB-340 treatment resulted in protective effect and lower grade of damage score in esophageal mucosa and gastric mucosa lesions vs effect of aspirin in single or 9 days applications. The serum levels of VCAM, IL-6 in rats who were aspirin-treated and subjected to stress-injury were higher than those in control animals. Treatment with ATB-340 produced an anti-inflammatory effect by decreasing VCAM and IL-6 vs aspirin. Cytoprotective effect of ATB-340 on esophageal mucosa and gastric mucosa was modulated by inhibiting inflammation and improving endothelial functions |
| first_indexed | 2024-03-11T13:50:47Z |
| format | Article |
| id | doaj.art-f6f44e42f3d5459cb8f48fa3a4a40de6 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T13:50:47Z |
| publishDate | 2017-04-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-f6f44e42f3d5459cb8f48fa3a4a40de62023-11-02T09:08:34ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032017-04-0189SI019310110.15407/ubj89.si01.093Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injuryO. S. Zayachkivska10 N. S. Bula11Ya. I. Pavlovskiy12 I. O. Pshyk-Titko13E. M. Gavriluk14O. I. Grushka15J. L. Wallace26Danylo Halytsky Lviv National Medical University, UkraineDanylo Halytsky Lviv National Medical University, UkraineDanylo Halytsky Lviv National Medical University, UkraineDanylo Halytsky Lviv National Medical University, UkraineDanylo Halytsky Lviv National Medical University, UkraineDanylo Halytsky Lviv National Medical University, UkraineUniversity of Calgary, CanadaRecent data of study H2S in gastrointestinal tract has proven its potent cytoprotection on mucosal defense among acid-related diseases in the gut. The aim was to evaluate the effects of H2S-releasing aspirin derivative (ATB-340) on esophageal and gastric mucosa compromised by stress injury. Rats were treated with vehicle (control), aspirin (10 mg/kg), ATB-340 (17.5 mg/kg) single or 9 days duration, with or without induction of stress injury. Esophageal mucosa, gastric mucosa were estimated by histopathological damage scoring. Serological levels of VCAM-1, IL-6 by ELISA. ATB-340 treatment resulted in protective effect and lower grade of damage score in esophageal mucosa and gastric mucosa lesions vs effect of aspirin in single or 9 days applications. The serum levels of VCAM, IL-6 in rats who were aspirin-treated and subjected to stress-injury were higher than those in control animals. Treatment with ATB-340 produced an anti-inflammatory effect by decreasing VCAM and IL-6 vs aspirin. Cytoprotective effect of ATB-340 on esophageal mucosa and gastric mucosa was modulated by inhibiting inflammation and improving endothelial functionshttp://ukrbiochemjournal.org/wp-content/uploads/2017/03/Zayachkivska_SI_01_17.pdf |
| spellingShingle | O. S. Zayachkivska1 N. S. Bula1 Ya. I. Pavlovskiy1 I. O. Pshyk-Titko1 E. M. Gavriluk1 O. I. Grushka1 J. L. Wallace2 Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury The Ukrainian Biochemical Journal |
| title | Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury |
| title_full | Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury |
| title_fullStr | Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury |
| title_full_unstemmed | Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury |
| title_short | Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury |
| title_sort | effect of hydrogen sulfide releasing aspirin on esophageal and gastric mucosa compromised by stress injury |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2017/03/Zayachkivska_SI_01_17.pdf |
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