Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B

Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B

Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberratio...

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Bibliographic Details
Main Authors: H. Akbaş, K. Yalcin, H. Isi, S. Tekes, A.E. Atay, Z. Akkus, T. Budak
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Hepatitis B
Chromosomal aberrations
Mitotic index
p53 gene codon 72 polymorphism
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100003&lng=en&tlng=en

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