A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche

A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche

Abstract Background The nutrient-absorbing villi of small intestines are renewed and repaired by intestinal stem cells (ISCs), which reside in a well-organized crypt structure. Genetic studies have shown that Wnt molecules secreted by telocytes, Gli1 + stromal cells, and epithelial cells are require...

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Bibliographic Details
Main Authors: Jinnan Xiang, Jigang Guo, Shaoyang Zhang, Hongguang Wu, Ye-Guang Chen, Junping Wang, Baojie Li, Huijuan Liu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Biology
Subjects:
Mesenchymal
Niche
ISC
Wntless
Paneth cell
Inflammation
Online Access:https://doi.org/10.1186/s12915-023-01667-2

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