Soyasaponin A1 inhibits the lipid raft recruitment and dimerization of TLR4, MyD88, and TRIF by maintaining cholesterol homeostasis in palmitic acid-stimulated inflammatory Raw264.7 macrophage cell line

Soyasaponin A1 inhibits the lipid raft recruitment and dimerization of TLR4, MyD88, and TRIF by maintaining cholesterol homeostasis in palmitic acid-stimulated inflammatory Raw264.7 macrophage cell line

The mechanisms of soyasaponin A1 (SS-A1) on antagonizing inflammation via regulating the lipid raft-mediated toll-like receptor 4 (TLR4) signaling are not completely understood. In this study, SS-A1 inhibited palmitic acid (PA)-induced recruitments of TLR4 and its adaptor molecules into lipid rafts...

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Bibliographic Details
Main Authors: Xiangfu Gu, Jiaqi Tang, Yue Zhao, Chuhong Su, Lingyu Xiao, Huiyu Luo, Yuguo Liu, Fei Xiong, Zhongdaixi Zheng, Junbin Chen, Longying Zha
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Functional Foods
Subjects:
Soyasaponin
Lipid raft
Inflammation
Toll-like receptor 4
Cholesterol homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621004382

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http://www.sciencedirect.com/science/article/pii/S1756464621004382

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