Experimental measurement and thermodynamic modeling of Chlorothiazide solubility in supercritical carbon dioxide

Experimental measurement and thermodynamic modeling of Chlorothiazide solubility in supercritical carbon dioxide

Chlorothiazide, with the brand name Diuril, is used as a diuretic as well as an antihypertensive drug. This medicine with very slight solubility in water and low permeability is categorized in the class IV of Biopharmaceutical Classification System (BCS) and possess low bioavailability. Therefore, e...

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Bibliographic Details
Main Authors:	Mohammed Majrashi, Ahmed Salah Al-Shati, Maria Grishina, Shaheen M. Sarkar, Minh-Tri Nguyen-Le, Saeed Shirazian
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Series:	Case Studies in Thermal Engineering
Subjects:	Pharmaceutics Chlorothiazide Thermodynamics Supercritical carbon dioxide Solubility Equation of state
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214157X22008589

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