Spermidine/spermine-N 1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

Spermidine/spermine-N 1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

Abstract Background Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine metabolism and tau fate. Polyamines exert an array of...

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Bibliographic Details
Main Authors: Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica, Kevin R. Nash, Marcia N. Gordon, Dave Morgan, Daniel C. Lee
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Tau
Polyamine dysregulation
Hippocampus
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13195-019-0507-y

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