Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus

Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus

Genome-wide analysis of thymic lymphomas from Tp53−/− mice with wild-type or C-terminally truncated Rag2 revealed numerous off-target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors mutated known and suspected oncogenes/tumor suppressor genes than did sporadic rearr...

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Bibliographic Details
Main Authors:	Martina Mijušković, Yi-Fan Chou, Vered Gigi, Cory R. Lindsay, Olga Shestova, Susanna M. Lewis, David B. Roth
Format:	Article
Language:	English
Published:	Elsevier 2015-09-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715009195

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