Pharmacological OGG1 inhibition decreases murine allergic airway inflammation

Pharmacological OGG1 inhibition decreases murine allergic airway inflammation

Background and aim: Allergic asthma is a complex inflammatory disease involving type 2 innate lymphoid cells, type 2 T helper cells, macrophages, and eosinophils. The disease is characterized by wheezing, dyspnea, coughing, chest tightness and variable airflow limitation for which there is no cure a...

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Bibliographic Details
Main Authors: Lloyd Tanner, Jesper Bergwik, Ravi K. V. Bhongir, Lang Pan, Caijuan Dong, Olov Wallner, Christina Kalderén, Thomas Helleday, Istvan Boldogh, Mikael Adner, Arne Egesten
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
allergic asthma
Ogg1
macrophage polarization
NF-κB
Th2 airway inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.999180/full

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