Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study
SNCA, GBA, and VPS35 are three common genes associated with Parkinson’s disease. Previous studies have shown that these three genes may be associated with Alzheimer’s disease (AD). However, it is unclear whether these genes increase the risk of AD in Chinese populations. In this study, we used a tar...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=682;epage=689;aulast=Wen |
| _version_ | 1818832884814839808 |
|---|---|
| author | Ya-Fei Wen Xue-Wen Xiao Lu Zhou Ya-Ling Jiang Yuan Zhu Li-Na Guo Xin Wang Hui Liu Ya-Fang Zhou Jun-Ling Wang Xin-Xin Liao Lu Shen Bin Jiao |
| author_facet | Ya-Fei Wen Xue-Wen Xiao Lu Zhou Ya-Ling Jiang Yuan Zhu Li-Na Guo Xin Wang Hui Liu Ya-Fang Zhou Jun-Ling Wang Xin-Xin Liao Lu Shen Bin Jiao |
| author_sort | Ya-Fei Wen |
| collection | DOAJ |
| description | SNCA, GBA, and VPS35 are three common genes associated with Parkinson’s disease. Previous studies have shown that these three genes may be associated with Alzheimer’s disease (AD). However, it is unclear whether these genes increase the risk of AD in Chinese populations. In this study, we used a targeted gene sequencing panel to screen all the exon regions and the nearby sequences of GBA, SNCA, and VPS35 in a cohort including 721 AD patients and 365 healthy controls from China. The results revealed that neither common variants nor rare variants of these three genes were associated with AD in a Chinese population. These findings suggest that the mutations in GBA, SNCA, and VPS35 are not likely to play an important role in the genetic susceptibility to AD in Chinese populations. The study was approved by the Ethics Committee of Xiangya Hospital, Central South University, China on March 9, 2016 (approval No. 201603198). |
| first_indexed | 2024-12-19T02:10:08Z |
| format | Article |
| id | doaj.art-f704e08bc8a84c6c94b7723f26831caa |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-19T02:10:08Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-f704e08bc8a84c6c94b7723f26831caa2022-12-21T20:40:49ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-0117368268910.4103/1673-5374.321000Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control studyYa-Fei WenXue-Wen XiaoLu ZhouYa-Ling JiangYuan ZhuLi-Na GuoXin WangHui LiuYa-Fang ZhouJun-Ling WangXin-Xin LiaoLu ShenBin JiaoSNCA, GBA, and VPS35 are three common genes associated with Parkinson’s disease. Previous studies have shown that these three genes may be associated with Alzheimer’s disease (AD). However, it is unclear whether these genes increase the risk of AD in Chinese populations. In this study, we used a targeted gene sequencing panel to screen all the exon regions and the nearby sequences of GBA, SNCA, and VPS35 in a cohort including 721 AD patients and 365 healthy controls from China. The results revealed that neither common variants nor rare variants of these three genes were associated with AD in a Chinese population. These findings suggest that the mutations in GBA, SNCA, and VPS35 are not likely to play an important role in the genetic susceptibility to AD in Chinese populations. The study was approved by the Ethics Committee of Xiangya Hospital, Central South University, China on March 9, 2016 (approval No. 201603198).http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=682;epage=689;aulast=Wenalzheimer’s disease; chinese population; common variants; gba; parkinson’s disease; rare variants; snca; vps35 |
| spellingShingle | Ya-Fei Wen Xue-Wen Xiao Lu Zhou Ya-Ling Jiang Yuan Zhu Li-Na Guo Xin Wang Hui Liu Ya-Fang Zhou Jun-Ling Wang Xin-Xin Liao Lu Shen Bin Jiao Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study Neural Regeneration Research alzheimer’s disease; chinese population; common variants; gba; parkinson’s disease; rare variants; snca; vps35 |
| title | Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study |
| title_full | Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study |
| title_fullStr | Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study |
| title_full_unstemmed | Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study |
| title_short | Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study |
| title_sort | mutations in gba snca and vps35 are not associated with alzheimer s disease in a chinese population a case control study |
| topic | alzheimer’s disease; chinese population; common variants; gba; parkinson’s disease; rare variants; snca; vps35 |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=682;epage=689;aulast=Wen |
| work_keys_str_mv | AT yafeiwen mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT xuewenxiao mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT luzhou mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT yalingjiang mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT yuanzhu mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT linaguo mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT xinwang mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT huiliu mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT yafangzhou mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT junlingwang mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT xinxinliao mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT lushen mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy AT binjiao mutationsingbasncaandvps35arenotassociatedwithalzheimersdiseaseinachinesepopulationacasecontrolstudy |