Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02244-2 |
| _version_ | 1818841534652481536 |
|---|---|
| author | Josephine Elia Grace Ungal Charlly Kao Alexander Ambrosini Nilsa De Jesus-Rosario Lene Larsen Rosetta Chiavacci Tiancheng Wang Christine Kurian Kanani Titchen Brian Sykes Sharon Hwang Bhumi Kumar Jacqueline Potts Joshua Davis Jeffrey Malatack Emma Slattery Ganesh Moorthy Athena Zuppa Andrew Weller Enda Byrne Yun R. Li Walter K. Kraft Hakon Hakonarson |
| author_facet | Josephine Elia Grace Ungal Charlly Kao Alexander Ambrosini Nilsa De Jesus-Rosario Lene Larsen Rosetta Chiavacci Tiancheng Wang Christine Kurian Kanani Titchen Brian Sykes Sharon Hwang Bhumi Kumar Jacqueline Potts Joshua Davis Jeffrey Malatack Emma Slattery Ganesh Moorthy Athena Zuppa Andrew Weller Enda Byrne Yun R. Li Walter K. Kraft Hakon Hakonarson |
| author_sort | Josephine Elia |
| collection | DOAJ |
| description | Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating symptoms of this disease. |
| first_indexed | 2024-12-19T04:27:37Z |
| format | Article |
| id | doaj.art-f704f752c78842ffbb277c912a01949b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:27:37Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f704f752c78842ffbb277c912a01949b2022-12-21T20:36:00ZengNature PortfolioNature Communications2041-17232018-01-01911910.1038/s41467-017-02244-2Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signalingJosephine Elia0Grace Ungal1Charlly Kao2Alexander Ambrosini3Nilsa De Jesus-Rosario4Lene Larsen5Rosetta Chiavacci6Tiancheng Wang7Christine Kurian8Kanani Titchen9Brian Sykes10Sharon Hwang11Bhumi Kumar12Jacqueline Potts13Joshua Davis14Jeffrey Malatack15Emma Slattery16Ganesh Moorthy17Athena Zuppa18Andrew Weller19Enda Byrne20Yun R. Li21Walter K. Kraft22Hakon Hakonarson23Nemours, du Pont Hospital for ChildrenDrexel University College of MedicineThe Center for Applied Genomics, The Children’s Hospital of PhiladelphiaUniversity of PennsylvaniaDepartment of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson UniversityDepartment of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson UniversityThe Center for Applied Genomics, The Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, The Children’s Hospital of PhiladelphiaDepartment of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson UniversityNemours, du Pont Hospital for ChildrenNemours, du Pont Hospital for ChildrenNemours, du Pont Hospital for ChildrenNemours, du Pont Hospital for ChildrenDepartment of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson UniversityNemours, du Pont Hospital for ChildrenNemours, du Pont Hospital for ChildrenDepartment of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson UniversityDepartment of Pediatrics Perelman School of Medicine, University of PennsylvaniaDepartment of Pediatrics Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson UniversityThe Center for Applied Genomics, The Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, The Children’s Hospital of PhiladelphiaDepartment of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson UniversityThe Center for Applied Genomics, The Children’s Hospital of PhiladelphiaStimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating symptoms of this disease.https://doi.org/10.1038/s41467-017-02244-2 |
| spellingShingle | Josephine Elia Grace Ungal Charlly Kao Alexander Ambrosini Nilsa De Jesus-Rosario Lene Larsen Rosetta Chiavacci Tiancheng Wang Christine Kurian Kanani Titchen Brian Sykes Sharon Hwang Bhumi Kumar Jacqueline Potts Joshua Davis Jeffrey Malatack Emma Slattery Ganesh Moorthy Athena Zuppa Andrew Weller Enda Byrne Yun R. Li Walter K. Kraft Hakon Hakonarson Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling Nature Communications |
| title | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling |
| title_full | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling |
| title_fullStr | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling |
| title_full_unstemmed | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling |
| title_short | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling |
| title_sort | fasoracetam in adolescents with adhd and glutamatergic gene network variants disrupting mglur neurotransmitter signaling |
| url | https://doi.org/10.1038/s41467-017-02244-2 |
| work_keys_str_mv | AT josephineelia fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT graceungal fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT charllykao fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT alexanderambrosini fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT nilsadejesusrosario fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT lenelarsen fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT rosettachiavacci fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT tianchengwang fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT christinekurian fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT kananititchen fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT briansykes fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT sharonhwang fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT bhumikumar fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT jacquelinepotts fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT joshuadavis fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT jeffreymalatack fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT emmaslattery fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT ganeshmoorthy fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT athenazuppa fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT andrewweller fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT endabyrne fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT yunrli fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT walterkkraft fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling AT hakonhakonarson fasoracetaminadolescentswithadhdandglutamatergicgenenetworkvariantsdisruptingmglurneurotransmittersignaling |