Automated glycan assembly of a S. pneumoniae serotype 3 CPS antigen

Automated glycan assembly of a S. pneumoniae serotype 3 CPS antigen

Vaccines against S. pneumoniae, one of the most prevalent bacterial infections causing severe disease, rely on isolated capsular polysaccharide (CPS) that are conjugated to proteins. Such isolates contain a heterogeneous oligosaccharide mixture of different chain lengths and frame shifts. Access to...

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Bibliographic Details
Main Authors: Markus W. Weishaupt, Stefan Matthies, Mattan Hurevich, Claney L. Pereira, Heung Sik Hahm, Peter H. Seeberger
Format: Article
Language:English
Published: Beilstein-Institut 2016-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
automation
glycosylation
protecting groups
oligosaccharides
solid-phase synthesis
Streptococcus pneumoniae
Online Access:https://doi.org/10.3762/bjoc.12.139

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