Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review
Helminth parasitoses are among the most prevalent health issues worldwide. Their control depends largely on unravelling host–parasite interactions, including parasitic exploitation of the host haemostatic system. The present study undertakes a scoping review of the research carried out in this field...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2022-01-01
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| Series: | Parasite |
| Subjects: | |
| Online Access: | https://www.parasite-journal.org/articles/parasite/full_html/2022/01/parasite220032/parasite220032.html |
| _version_ | 1797642340742987776 |
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| author | Diosdado Alicia Simón Fernando Serrat Judit González-Miguel Javier |
| author_facet | Diosdado Alicia Simón Fernando Serrat Judit González-Miguel Javier |
| author_sort | Diosdado Alicia |
| collection | DOAJ |
| description | Helminth parasitoses are among the most prevalent health issues worldwide. Their control depends largely on unravelling host–parasite interactions, including parasitic exploitation of the host haemostatic system. The present study undertakes a scoping review of the research carried out in this field with the aim of unifying and updating concepts. Multiple keywords combined with Boolean operators were employed to design the literature search strategy. Two online databases were used to identify original peer-reviewed articles written in English and published before 1st January 2020 describing molecular interactions between helminth parasites and the host haemostatic system. Relevant data from the selected sources of evidence were extracted and analysed. Ninety-six publications reporting 259 interactions were selected. Fifty-three proteins belonging to 32 species of helminth parasites were involved in interactions with components of the host haemostatic system. Many of these proteins from both parasite and host were conserved among the different interactions identified. Most of these interactions were related to the inhibition of the coagulation system and the activation of fibrinolysis. This was associated mainly with a potential of parasites to reduce the formation of blood clots in the host and attributed to biological processes, such as parasite nutrition, survival, invasion, evasion and migration or the appearance of pathological mechanisms in the host. A wide range of helminth parasites have developed similar strategies to exploit the haemostatic system of their hosts, which could be regarded as an evolutionary conserved mechanism that could confer benefits to parasites in terms of survival and establishment in their vertebrate hosts. |
| first_indexed | 2024-03-11T13:58:40Z |
| format | Article |
| id | doaj.art-f705325b28b549d39caf5c106a3e8927 |
| institution | Directory Open Access Journal |
| issn | 1776-1042 |
| language | English |
| last_indexed | 2024-03-11T13:58:40Z |
| publishDate | 2022-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-f705325b28b549d39caf5c106a3e89272023-11-02T05:44:40ZengEDP SciencesParasite1776-10422022-01-01293510.1051/parasite/2022034parasite220032Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping reviewDiosdado Alicia0Simón Fernando1Serrat Judit2González-Miguel Javier3https://orcid.org/0000-0003-4279-4761Laboratory of Parasitology, Faculty of Pharmacy, University of SalamancaLaboratory of Parasitology, Faculty of Pharmacy, University of SalamancaLaboratory of Parasitology, Institute of Natural Resources and Agrobiology of Salamanca (IRNASA-CSIC)Laboratory of Parasitology, Institute of Natural Resources and Agrobiology of Salamanca (IRNASA-CSIC)Helminth parasitoses are among the most prevalent health issues worldwide. Their control depends largely on unravelling host–parasite interactions, including parasitic exploitation of the host haemostatic system. The present study undertakes a scoping review of the research carried out in this field with the aim of unifying and updating concepts. Multiple keywords combined with Boolean operators were employed to design the literature search strategy. Two online databases were used to identify original peer-reviewed articles written in English and published before 1st January 2020 describing molecular interactions between helminth parasites and the host haemostatic system. Relevant data from the selected sources of evidence were extracted and analysed. Ninety-six publications reporting 259 interactions were selected. Fifty-three proteins belonging to 32 species of helminth parasites were involved in interactions with components of the host haemostatic system. Many of these proteins from both parasite and host were conserved among the different interactions identified. Most of these interactions were related to the inhibition of the coagulation system and the activation of fibrinolysis. This was associated mainly with a potential of parasites to reduce the formation of blood clots in the host and attributed to biological processes, such as parasite nutrition, survival, invasion, evasion and migration or the appearance of pathological mechanisms in the host. A wide range of helminth parasites have developed similar strategies to exploit the haemostatic system of their hosts, which could be regarded as an evolutionary conserved mechanism that could confer benefits to parasites in terms of survival and establishment in their vertebrate hosts.https://www.parasite-journal.org/articles/parasite/full_html/2022/01/parasite220032/parasite220032.htmlhelminth parasiteshaemostatic systemcoagulationfibrinolysishost–parasite relationshipsscoping review |
| spellingShingle | Diosdado Alicia Simón Fernando Serrat Judit González-Miguel Javier Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review Parasite helminth parasites haemostatic system coagulation fibrinolysis host–parasite relationships scoping review |
| title | Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review |
| title_full | Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review |
| title_fullStr | Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review |
| title_full_unstemmed | Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review |
| title_short | Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review |
| title_sort | interaction of helminth parasites with the haemostatic system of their vertebrate hosts a scoping review |
| topic | helminth parasites haemostatic system coagulation fibrinolysis host–parasite relationships scoping review |
| url | https://www.parasite-journal.org/articles/parasite/full_html/2022/01/parasite220032/parasite220032.html |
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