From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic Aneurysm
Thoracic aortic aneurysms (TAAs) are commonly seen in cardiovascular practice. Acquired and genetic conditions contribute to TAA formation. The natural history of genetically mediated TAA underscores the importance of early detection, regular monitoring, and prompt treatment to prevent complications...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cardiogenetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2035-8148/13/4/15 |
| _version_ | 1797381703818280960 |
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| author | Yuliya Paulenka Christopher Lee Mays Tawayha Sam Dow Kajal Shah Stanislav Henkin Wassim Mosleh |
| author_facet | Yuliya Paulenka Christopher Lee Mays Tawayha Sam Dow Kajal Shah Stanislav Henkin Wassim Mosleh |
| author_sort | Yuliya Paulenka |
| collection | DOAJ |
| description | Thoracic aortic aneurysms (TAAs) are commonly seen in cardiovascular practice. Acquired and genetic conditions contribute to TAA formation. The natural history of genetically mediated TAA underscores the importance of early detection, regular monitoring, and prompt treatment to prevent complications, including dissection or rupture. The prognosis is poor in the event of acute dissection, with high rates of in-hospital mortality. Healthcare providers need to remain vigilant in their efforts to identify and surveil TAA to reduce the risk of complications. In this manuscript, we review the natural history of TAA, discuss the most common causes leading to the development of TAA, assess the value and limitations of diagnostic modalities, and review the management and long-term surveillance of patients with aortic disease. |
| first_indexed | 2024-03-08T20:55:15Z |
| format | Article |
| id | doaj.art-f709e6f81bc84a899be49b82020c62e2 |
| institution | Directory Open Access Journal |
| issn | 2035-8253 2035-8148 |
| language | English |
| last_indexed | 2024-03-08T20:55:15Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cardiogenetics |
| spelling | doaj.art-f709e6f81bc84a899be49b82020c62e22023-12-22T13:59:19ZengMDPI AGCardiogenetics2035-82532035-81482023-11-0113415417210.3390/cardiogenetics13040015From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic AneurysmYuliya Paulenka0Christopher Lee1Mays Tawayha2Sam Dow3Kajal Shah4Stanislav Henkin5Wassim Mosleh6Department of Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USADivision of Cardiology, University of California, San Francisco, CA 93106, USASchool of Medicine, Jordan University of Science and Technology, Irbid 3030, JordanHeart and Vascular Center, Interventional Cardiology | Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USAHeart and Vascular Center, Interventional Cardiology | Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USAGonda Vascular Center, Mayo Clinic, Rochester, MN 55901, USAHeart and Vascular Center, Interventional Cardiology | Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USAThoracic aortic aneurysms (TAAs) are commonly seen in cardiovascular practice. Acquired and genetic conditions contribute to TAA formation. The natural history of genetically mediated TAA underscores the importance of early detection, regular monitoring, and prompt treatment to prevent complications, including dissection or rupture. The prognosis is poor in the event of acute dissection, with high rates of in-hospital mortality. Healthcare providers need to remain vigilant in their efforts to identify and surveil TAA to reduce the risk of complications. In this manuscript, we review the natural history of TAA, discuss the most common causes leading to the development of TAA, assess the value and limitations of diagnostic modalities, and review the management and long-term surveillance of patients with aortic disease.https://www.mdpi.com/2035-8148/13/4/15aortic diseaseaortic aneurysmaortic dissectiongeneticsMarfan syndromeLoeys–Dietz |
| spellingShingle | Yuliya Paulenka Christopher Lee Mays Tawayha Sam Dow Kajal Shah Stanislav Henkin Wassim Mosleh From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic Aneurysm Cardiogenetics aortic disease aortic aneurysm aortic dissection genetics Marfan syndrome Loeys–Dietz |
| title | From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic Aneurysm |
| title_full | From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic Aneurysm |
| title_fullStr | From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic Aneurysm |
| title_full_unstemmed | From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic Aneurysm |
| title_short | From Natural History to Contemporary Management of Aortic Diseases: A State-of-the-Art Review of Thoracic Aortic Aneurysm |
| title_sort | from natural history to contemporary management of aortic diseases a state of the art review of thoracic aortic aneurysm |
| topic | aortic disease aortic aneurysm aortic dissection genetics Marfan syndrome Loeys–Dietz |
| url | https://www.mdpi.com/2035-8148/13/4/15 |
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