Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review
The endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of sustaining the microenvironment necessary for early pregnancy success and maintenance. It plays a significant role in embryo development, transport and implantation as well as pla...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.699951/full |
| _version_ | 1818613474468560896 |
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| author | Melissa L. Kozakiewicz Chad A. Grotegut Allyn C. Howlett |
| author_facet | Melissa L. Kozakiewicz Chad A. Grotegut Allyn C. Howlett |
| author_sort | Melissa L. Kozakiewicz |
| collection | DOAJ |
| description | The endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of sustaining the microenvironment necessary for early pregnancy success and maintenance. It plays a significant role in embryo development, transport and implantation as well as placentation. The current theory behind the initiation of term labor is that it is a complex, multifactorial process involving sex steroid hormones, prostaglandin production and interplay at the maternal-fetal interface resulting in increased expression of receptors and gap junctions that promote uterine activation. There is increasing evidence that, in addition to early pregnancy events, the ECS plays a regulatory role in pregnancy maintenance and the timing of labor. This review presents an overview of the ECS in pregnancy that focuses on late gestation and parturition. |
| first_indexed | 2024-12-16T16:02:42Z |
| format | Article |
| id | doaj.art-f70a578b263f4fc6bb44736ea1faad84 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T16:02:42Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f70a578b263f4fc6bb44736ea1faad842022-12-21T22:25:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-06-011210.3389/fendo.2021.699951699951Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-ReviewMelissa L. Kozakiewicz0Chad A. Grotegut1Allyn C. Howlett2Department of Obstetrics and Gynecology, Section on Maternal-Fetal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United StatesDepartment of Obstetrics and Gynecology, Section on Maternal-Fetal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United StatesDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United StatesThe endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of sustaining the microenvironment necessary for early pregnancy success and maintenance. It plays a significant role in embryo development, transport and implantation as well as placentation. The current theory behind the initiation of term labor is that it is a complex, multifactorial process involving sex steroid hormones, prostaglandin production and interplay at the maternal-fetal interface resulting in increased expression of receptors and gap junctions that promote uterine activation. There is increasing evidence that, in addition to early pregnancy events, the ECS plays a regulatory role in pregnancy maintenance and the timing of labor. This review presents an overview of the ECS in pregnancy that focuses on late gestation and parturition.https://www.frontiersin.org/articles/10.3389/fendo.2021.699951/fullendocannabinoid systemmyometriumlaborparturitionanandamidecannabinoid receptor |
| spellingShingle | Melissa L. Kozakiewicz Chad A. Grotegut Allyn C. Howlett Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review Frontiers in Endocrinology endocannabinoid system myometrium labor parturition anandamide cannabinoid receptor |
| title | Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review |
| title_full | Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review |
| title_fullStr | Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review |
| title_full_unstemmed | Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review |
| title_short | Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review |
| title_sort | endocannabinoid system in pregnancy maintenance and labor a mini review |
| topic | endocannabinoid system myometrium labor parturition anandamide cannabinoid receptor |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.699951/full |
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