Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis
Owing to the rarity of post-infectious bronchiolitis obliterans (PIBO), pulmonary function in children with PIBO has been mainly investigated in small-sample sized studies. This systematic review and meta-analysis investigated pulmonary function in children with PIBO, regardless of age at respirator...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/12/1538 |
| _version_ | 1827637426241142784 |
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| author | Eun Lee Suyeon Park Hyeon-Jong Yang |
| author_facet | Eun Lee Suyeon Park Hyeon-Jong Yang |
| author_sort | Eun Lee |
| collection | DOAJ |
| description | Owing to the rarity of post-infectious bronchiolitis obliterans (PIBO), pulmonary function in children with PIBO has been mainly investigated in small-sample sized studies. This systematic review and meta-analysis investigated pulmonary function in children with PIBO, regardless of age at respiratory insult and PIBO diagnosis. A systematic literature search revealed 16 studies reporting pulmonary function data in 480 children with PIBO. Levels of key pulmonary function parameters were summarized by pooled mean difference (MD) only in children with PIBO, and a random effect model was used. Pooled MDs (95% confidence interval [CI]) for FEV<sub>1</sub>, FVC, and FEF<sub>25–75%</sub> were 51.4, (44.2 to 58.5), 68.4 (64.4 to 72.3), and 26.5 (19.3 to 33.6) % predicted, respectively, with FEV<sub>1</sub>/FVC of 68.8% (62.2 to 75.4). Pooled MDs (95% CI) of the z-scores for FEV<sub>1</sub>, FVC, and FEF<sub>25–75%</sub> were −2.6 (−4.2 to −0.9), −1.9 (−3.2 to −0.5), and −2.0 (−3.6 to −0.4). Pooled MD (95% CI) for the diffusion capacity of the lungs for carbon monoxide from two studies was 64.9 (45.6 to 84.3) % predicted. The post-bronchodilator use change in the FEV<sub>1</sub> in three studies was 6.1 (4.9 to 7.2). There was considerable heterogeneity across the studies. PIBO is associated with moderately impaired pulmonary function, and this review facilitates an understanding of PIBO pathophysiology in children. |
| first_indexed | 2024-03-09T15:59:53Z |
| format | Article |
| id | doaj.art-f70a8bd97a954c9a856644cf3e6c84a5 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T15:59:53Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-f70a8bd97a954c9a856644cf3e6c84a52023-11-24T17:14:26ZengMDPI AGPathogens2076-08172022-12-011112153810.3390/pathogens11121538Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-AnalysisEun Lee0Suyeon Park1Hyeon-Jong Yang2Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of KoreaDepartment of Applied Statistics, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Pediatrics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul 04401, Republic of KoreaOwing to the rarity of post-infectious bronchiolitis obliterans (PIBO), pulmonary function in children with PIBO has been mainly investigated in small-sample sized studies. This systematic review and meta-analysis investigated pulmonary function in children with PIBO, regardless of age at respiratory insult and PIBO diagnosis. A systematic literature search revealed 16 studies reporting pulmonary function data in 480 children with PIBO. Levels of key pulmonary function parameters were summarized by pooled mean difference (MD) only in children with PIBO, and a random effect model was used. Pooled MDs (95% confidence interval [CI]) for FEV<sub>1</sub>, FVC, and FEF<sub>25–75%</sub> were 51.4, (44.2 to 58.5), 68.4 (64.4 to 72.3), and 26.5 (19.3 to 33.6) % predicted, respectively, with FEV<sub>1</sub>/FVC of 68.8% (62.2 to 75.4). Pooled MDs (95% CI) of the z-scores for FEV<sub>1</sub>, FVC, and FEF<sub>25–75%</sub> were −2.6 (−4.2 to −0.9), −1.9 (−3.2 to −0.5), and −2.0 (−3.6 to −0.4). Pooled MD (95% CI) for the diffusion capacity of the lungs for carbon monoxide from two studies was 64.9 (45.6 to 84.3) % predicted. The post-bronchodilator use change in the FEV<sub>1</sub> in three studies was 6.1 (4.9 to 7.2). There was considerable heterogeneity across the studies. PIBO is associated with moderately impaired pulmonary function, and this review facilitates an understanding of PIBO pathophysiology in children.https://www.mdpi.com/2076-0817/11/12/1538childrenpost-infectious bronchiolitis obliteranspulmonary function tests |
| spellingShingle | Eun Lee Suyeon Park Hyeon-Jong Yang Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis Pathogens children post-infectious bronchiolitis obliterans pulmonary function tests |
| title | Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis |
| title_full | Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis |
| title_fullStr | Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis |
| title_short | Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis |
| title_sort | pulmonary function in post infectious bronchiolitis obliterans in children a systematic review and meta analysis |
| topic | children post-infectious bronchiolitis obliterans pulmonary function tests |
| url | https://www.mdpi.com/2076-0817/11/12/1538 |
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