Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trials
Abstract Background and Aims Previous studies have shown that supplementation of some amino acids such as l‐arginine or its precursors could exert beneficial effects in patients with sickle cell disease (SCD). The objective of this study is to systematically review the literature to assess the effec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1167 |
| _version_ | 1797839774198792192 |
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| author | Alireza Sadeghi Ehsan Taherifard Niloofar Dehdari Ebrahimi Elham Rafiei Farshad Hadianfard Erfan Taherifard |
| author_facet | Alireza Sadeghi Ehsan Taherifard Niloofar Dehdari Ebrahimi Elham Rafiei Farshad Hadianfard Erfan Taherifard |
| author_sort | Alireza Sadeghi |
| collection | DOAJ |
| description | Abstract Background and Aims Previous studies have shown that supplementation of some amino acids such as l‐arginine or its precursors could exert beneficial effects in patients with sickle cell disease (SCD). The objective of this study is to systematically review the literature to assess the effect of arginine administration on the clinical and paraclinical parameters of patients with SCD. Methods Four online databases of PubMed, Web of Sciences, Scopus, and Embase were selected for systematic search. Eligible studies were clinical trials that evaluated the effect of arginine usage in patients with SCD. Effects sizes were calculated using weighted mean difference (WMD) and Hedge's g and they were pooled using random‐effects modeling with Hartung–Knapp adjustment. Additional analyses were also conducted. Results Twelve studies containing detail of 399 patients with SCD were found to be eligible. The data synthesis showed that l‐arginine significantly increased the level of NO metabolites (Hedge's g: 1.50, 0.48–1.82, I2: 88%) and hemoglobin F (WMD: 1.69%, 0.86–2.52, I2: 0%) and significantly decreased systolic blood pressure (WMD: −8.46 mmHg, −15.58 to −1.33, I2: 53%) and aspartate transaminase (Hedge's g: −0.49, −0.73 to −0.26, I2: 0%). However, there were no significant effects on hemoglobin, reticulocyte, malondialdehyde and diastolic blood pressure, and alanine transaminase. Conclusion Our meta‐analysis showed that l‐arginine use for SCD could be beneficial, increase hemoglobin F and exert blood pressure‐lowering and hepatoprotective properties. However, for a firm conclusion and widespread use of l‐arginine for these patients, more studies are needed. |
| first_indexed | 2024-04-09T16:03:32Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-04-09T16:03:32Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-f70e73952f264660a3102094b39dd4222023-04-25T08:04:33ZengWileyHealth Science Reports2398-88352023-04-0164n/an/a10.1002/hsr2.1167Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trialsAlireza Sadeghi0Ehsan Taherifard1Niloofar Dehdari Ebrahimi2Elham Rafiei3Farshad Hadianfard4Erfan Taherifard5Student Research Committee Shiraz University of Medical Sciences Shiraz IranInternal Medicine Department Shiraz University of Medical Sciences Shiraz IranStudent Research Committee Shiraz University of Medical Sciences Shiraz IranStudent Research Committee Shiraz University of Medical Sciences Shiraz IranStudent Research Committee Shiraz University of Medical Sciences Shiraz IranInternal Medicine Department Shiraz University of Medical Sciences Shiraz IranAbstract Background and Aims Previous studies have shown that supplementation of some amino acids such as l‐arginine or its precursors could exert beneficial effects in patients with sickle cell disease (SCD). The objective of this study is to systematically review the literature to assess the effect of arginine administration on the clinical and paraclinical parameters of patients with SCD. Methods Four online databases of PubMed, Web of Sciences, Scopus, and Embase were selected for systematic search. Eligible studies were clinical trials that evaluated the effect of arginine usage in patients with SCD. Effects sizes were calculated using weighted mean difference (WMD) and Hedge's g and they were pooled using random‐effects modeling with Hartung–Knapp adjustment. Additional analyses were also conducted. Results Twelve studies containing detail of 399 patients with SCD were found to be eligible. The data synthesis showed that l‐arginine significantly increased the level of NO metabolites (Hedge's g: 1.50, 0.48–1.82, I2: 88%) and hemoglobin F (WMD: 1.69%, 0.86–2.52, I2: 0%) and significantly decreased systolic blood pressure (WMD: −8.46 mmHg, −15.58 to −1.33, I2: 53%) and aspartate transaminase (Hedge's g: −0.49, −0.73 to −0.26, I2: 0%). However, there were no significant effects on hemoglobin, reticulocyte, malondialdehyde and diastolic blood pressure, and alanine transaminase. Conclusion Our meta‐analysis showed that l‐arginine use for SCD could be beneficial, increase hemoglobin F and exert blood pressure‐lowering and hepatoprotective properties. However, for a firm conclusion and widespread use of l‐arginine for these patients, more studies are needed.https://doi.org/10.1002/hsr2.1167argininemeta‐analysissickle cell disease |
| spellingShingle | Alireza Sadeghi Ehsan Taherifard Niloofar Dehdari Ebrahimi Elham Rafiei Farshad Hadianfard Erfan Taherifard Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trials Health Science Reports arginine meta‐analysis sickle cell disease |
| title | Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trials |
| title_full | Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trials |
| title_fullStr | Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trials |
| title_full_unstemmed | Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trials |
| title_short | Effects of l‐arginine supplementation in patients with sickle cell disease: A systematic review and meta‐analysis of clinical trials |
| title_sort | effects of l arginine supplementation in patients with sickle cell disease a systematic review and meta analysis of clinical trials |
| topic | arginine meta‐analysis sickle cell disease |
| url | https://doi.org/10.1002/hsr2.1167 |
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