Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women
Abstract Oxytocin administration during a trauma analogue has been shown to increase intrusive memories, which are a core symptom of post-traumatic stress disorder (PTSD). However, it is unknown whether oxytocin influences the acquisition or the consolidation of the trauma. The current study investi...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
|
| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02339-z |
| _version_ | 1811171540938522624 |
|---|---|
| author | Tolou Maslahati Katja Wingenfeld Julian Hellmann-Regen Julia Kraft Jing Lyu Marie Keinert Aline Voß An Bin Cho Stephan Ripke Christian Otte Katharina Schultebraucks Stefan Roepke |
| author_facet | Tolou Maslahati Katja Wingenfeld Julian Hellmann-Regen Julia Kraft Jing Lyu Marie Keinert Aline Voß An Bin Cho Stephan Ripke Christian Otte Katharina Schultebraucks Stefan Roepke |
| author_sort | Tolou Maslahati |
| collection | DOAJ |
| description | Abstract Oxytocin administration during a trauma analogue has been shown to increase intrusive memories, which are a core symptom of post-traumatic stress disorder (PTSD). However, it is unknown whether oxytocin influences the acquisition or the consolidation of the trauma. The current study investigates the effect of the activation of the oxytocin system during the consolidation of an analogue trauma on the formation of intrusive memories over four consecutive days and whether this effect is influenced by individual neurobiological, genetic, or psychological factors. We conducted a randomized double-blind placebo-controlled study in 217 healthy women. They received either a single dose of intranasal oxytocin (24 IU) or placebo after exposure to a trauma film paradigm, which reliably induces intrusive memories. We used a general random forest to examine a potential heterogeneous treatment effect of oxytocin on the consolidation of intrusive memories. Furthermore, we used a poisson regression to examine whether salivary alpha amylase activity (sAA) as a marker of noradrenergic activity and cortisol response to the film, polygenic risk score (PRS) for psychiatric disorders, and psychological factors influence the number of intrusive memories. We found no significant effect of oxytocin on the formation of intrusive memories (F(2, 543.16) = 0.75, p = 0.51, ηp2 = 0.00) and identified no heterogeneous treatment effect. We replicated previous associations of the PRS for PTSD, sAA and the cortisol response on intrusive memories. We further found a positive association between high trait anxiety and intrusive memories, and a negative association between the emotion regulation strategy reappraisal and intrusive memories. Data of the present study suggest that the consolidation of intrusive memories in women is modulated by genetic, neurobiological and psychological factors, but is not influenced by oxytocin. Trial registration: NCT03875391. |
| first_indexed | 2024-04-10T17:16:46Z |
| format | Article |
| id | doaj.art-f70f39fcd753479f98332f250189e725 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-10T17:16:46Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-f70f39fcd753479f98332f250189e7252023-02-05T12:24:43ZengNature Publishing GroupTranslational Psychiatry2158-31882023-02-011311810.1038/s41398-023-02339-zOxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy womenTolou Maslahati0Katja Wingenfeld1Julian Hellmann-Regen2Julia Kraft3Jing Lyu4Marie Keinert5Aline Voß6An Bin Cho7Stephan Ripke8Christian Otte9Katharina Schultebraucks10Stefan Roepke11Department of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Biostatistics, Columbia University, Mailman School of Public HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, CBF, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthAbstract Oxytocin administration during a trauma analogue has been shown to increase intrusive memories, which are a core symptom of post-traumatic stress disorder (PTSD). However, it is unknown whether oxytocin influences the acquisition or the consolidation of the trauma. The current study investigates the effect of the activation of the oxytocin system during the consolidation of an analogue trauma on the formation of intrusive memories over four consecutive days and whether this effect is influenced by individual neurobiological, genetic, or psychological factors. We conducted a randomized double-blind placebo-controlled study in 217 healthy women. They received either a single dose of intranasal oxytocin (24 IU) or placebo after exposure to a trauma film paradigm, which reliably induces intrusive memories. We used a general random forest to examine a potential heterogeneous treatment effect of oxytocin on the consolidation of intrusive memories. Furthermore, we used a poisson regression to examine whether salivary alpha amylase activity (sAA) as a marker of noradrenergic activity and cortisol response to the film, polygenic risk score (PRS) for psychiatric disorders, and psychological factors influence the number of intrusive memories. We found no significant effect of oxytocin on the formation of intrusive memories (F(2, 543.16) = 0.75, p = 0.51, ηp2 = 0.00) and identified no heterogeneous treatment effect. We replicated previous associations of the PRS for PTSD, sAA and the cortisol response on intrusive memories. We further found a positive association between high trait anxiety and intrusive memories, and a negative association between the emotion regulation strategy reappraisal and intrusive memories. Data of the present study suggest that the consolidation of intrusive memories in women is modulated by genetic, neurobiological and psychological factors, but is not influenced by oxytocin. Trial registration: NCT03875391.https://doi.org/10.1038/s41398-023-02339-z |
| spellingShingle | Tolou Maslahati Katja Wingenfeld Julian Hellmann-Regen Julia Kraft Jing Lyu Marie Keinert Aline Voß An Bin Cho Stephan Ripke Christian Otte Katharina Schultebraucks Stefan Roepke Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women Translational Psychiatry |
| title | Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women |
| title_full | Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women |
| title_fullStr | Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women |
| title_full_unstemmed | Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women |
| title_short | Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women |
| title_sort | oxytocin vs placebo effects on intrusive memory consolidation using a trauma film paradigm a randomized controlled experimental study in healthy women |
| url | https://doi.org/10.1038/s41398-023-02339-z |
| work_keys_str_mv | AT toloumaslahati oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT katjawingenfeld oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT julianhellmannregen oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT juliakraft oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT jinglyu oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT mariekeinert oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT alinevoß oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT anbincho oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT stephanripke oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT christianotte oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT katharinaschultebraucks oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen AT stefanroepke oxytocinvsplaceboeffectsonintrusivememoryconsolidationusingatraumafilmparadigmarandomizedcontrolledexperimentalstudyinhealthywomen |