Centrally Acting Angiotensin-Converting Enzyme Inhibitor Suppresses Type I Interferon Responses and Decreases Inflammation in the Periphery and the CNS in Lupus-Prone Mice

Centrally Acting Angiotensin-Converting Enzyme Inhibitor Suppresses Type I Interferon Responses and Decreases Inflammation in the Periphery and the CNS in Lupus-Prone Mice

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-organ damage. Neuropsychiatric lupus (NPSLE) is one of the most common manifestations of human SLE, often causing depression. Interferon-α (IFNα) is a central mediator in disease pathogenesis. Administration of IFNα t...

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Bibliographic Details
Main Authors: Cassandra Nocito, Cody Lubinsky, Michelle Hand, Sabeeya Khan, Tulsi Patel, Alecia Seliga, Malika Winfield, Viviana Zuluaga-Ramirez, Nicole Fernandes, Xiangdang Shi, Ellen M. Unterwald, Yuri Persidsky, Uma Sriram
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
type I interferon
angiotensin-converting enzyme inhibitor
captopril
immune complex
neuroinflammation
serotonin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.573677/full

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