Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report
Alternative therapies are necessary to treat catatonia in patients with comorbidities that are not amenable to therapy with benzodiazepines or ECT. This is a patient with schizophrenia with catatonic features and a history of polysubstance abuse. Consequently, he was not a candidate for treatment wi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The University of Toledo
2021-02-01
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| Series: | Translation |
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| Online Access: | https://openjournals.utoledo.edu/index.php/translation/article/view/450 |
| _version_ | 1818865753386909696 |
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| author | Jacob Maier Daniel Rapport Alex McCormick Chandani Lewis |
| author_facet | Jacob Maier Daniel Rapport Alex McCormick Chandani Lewis |
| author_sort | Jacob Maier |
| collection | DOAJ |
| description | Alternative therapies are necessary to treat catatonia in patients with comorbidities that are not amenable to therapy with benzodiazepines or ECT. This is a patient with schizophrenia with catatonic features and a history of polysubstance abuse. Consequently, he was not a candidate for treatment with benzodiazepines, so an alternative needed to be found. GABAergic medications have been used previously as alternatives to benzodiazepines and ECT. In this case we chose sodium valproate, due to its cross-reaction with GABAergic systems. There are five reported cases using sodium valproate. Three of which were treated with intravenous valproate, while the remaining two do not specify the route of administration. We present a case where oral sodium valproate was used successfully for both acute and long-term catatonic treatment. To our knowledge, no other report has looked at both acute and long-term treatment with sodium valproate. Oral sodium valproate can be considered for patients with substance use disorders like COPD, sleep apnea or myasthenia gravis in which benzodiazepines are contraindicated and where ECT is not an option for treatment. |
| first_indexed | 2024-12-19T10:52:33Z |
| format | Article |
| id | doaj.art-f70fc2eb13eb44b08bb65a0f36f5b412 |
| institution | Directory Open Access Journal |
| issn | 2469-6706 |
| language | English |
| last_indexed | 2024-12-19T10:52:33Z |
| publishDate | 2021-02-01 |
| publisher | The University of Toledo |
| record_format | Article |
| series | Translation |
| spelling | doaj.art-f70fc2eb13eb44b08bb65a0f36f5b4122022-12-21T20:24:57ZengThe University of ToledoTranslation2469-67062021-02-01810.46570/utjms.vol8-2020-450Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case ReportJacob Maier0Daniel Rapport1Alex McCormick2Chandani Lewis3The University of Toledo School of Medicine The University of Toledo Medical CenterNorthcoast Behavioral HealthcareThe University of Toledo Medical Center Alternative therapies are necessary to treat catatonia in patients with comorbidities that are not amenable to therapy with benzodiazepines or ECT. This is a patient with schizophrenia with catatonic features and a history of polysubstance abuse. Consequently, he was not a candidate for treatment with benzodiazepines, so an alternative needed to be found. GABAergic medications have been used previously as alternatives to benzodiazepines and ECT. In this case we chose sodium valproate, due to its cross-reaction with GABAergic systems. There are five reported cases using sodium valproate. Three of which were treated with intravenous valproate, while the remaining two do not specify the route of administration. We present a case where oral sodium valproate was used successfully for both acute and long-term catatonic treatment. To our knowledge, no other report has looked at both acute and long-term treatment with sodium valproate. Oral sodium valproate can be considered for patients with substance use disorders like COPD, sleep apnea or myasthenia gravis in which benzodiazepines are contraindicated and where ECT is not an option for treatment.https://openjournals.utoledo.edu/index.php/translation/article/view/450catatoniadepakotesodium valproateschizophrenia |
| spellingShingle | Jacob Maier Daniel Rapport Alex McCormick Chandani Lewis Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report Translation catatonia depakote sodium valproate schizophrenia |
| title | Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report |
| title_full | Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report |
| title_fullStr | Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report |
| title_full_unstemmed | Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report |
| title_short | Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report |
| title_sort | oral valproate sodium as an alternative to benzodiazepine in the treatment of catatonia a case report |
| topic | catatonia depakote sodium valproate schizophrenia |
| url | https://openjournals.utoledo.edu/index.php/translation/article/view/450 |
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