A rapid real-time quantitative PCR assay to determine the minimal inhibitory extracellular concentration of antibiotics against an intracellular Francisella tularensis Live Vaccine Strain

A rapid real-time quantitative PCR assay to determine the minimal inhibitory extracellular concentration of antibiotics against an intracellular Francisella tularensis Live Vaccine Strain

Francisella tularensis is a highly virulent facultative intracellular bacterium. The lack of a safe and efficient vaccine makes antibiotics the preferred treatment. F. tularensis antibiotic susceptibility tests are based on the in vitro standard CLSI-approved microdilution method for determining the...

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Bibliographic Details
Main Authors: Ronit eAloni-Grinstein, Ohad eShifman, Shlomi eLazar, Ida eSteinberger-Levy, Sharon eMaoz, Raphael eBer
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Microbiology
Subjects:
Francisella tularensis
Tularemia
qPCR
antibiotic susceptibility
MIC
Intracellular infection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01213/full

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