Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia
The essential oil (EO) of Artemisia plants contains a large number of bioactive compounds that are widely used. The aim of this study was to analyse the chemical composition of EOs of six Artemisia plants collected in Croatia and to test their cholinesterase inhibitory potential. GC–MS analysis of t...
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MDPI AG
2023-10-01
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| author | Olivera Politeo Ivana Cajic Anja Simic Mirko Ruscic Mejra Bektasevic |
| author_facet | Olivera Politeo Ivana Cajic Anja Simic Mirko Ruscic Mejra Bektasevic |
| author_sort | Olivera Politeo |
| collection | DOAJ |
| description | The essential oil (EO) of Artemisia plants contains a large number of bioactive compounds that are widely used. The aim of this study was to analyse the chemical composition of EOs of six Artemisia plants collected in Croatia and to test their cholinesterase inhibitory potential. GC–MS analysis of the EO of <i>A. absinthium</i> showed that the dominant compounds are <i>cis</i>-sabinyl acetate and <i>cis</i>-epoxy-ocimene; in EO of <i>A. abrotanum</i>, it is borneol; in the EO of <i>A. annua</i>, they are artemisia ketone, camphor and 1,8-cineole; in the EO of <i>A. arborescens</i>, they are camphor and chamazulene; in the EO of <i>A. verlotiorum</i>, they are <i>cis</i>-thujone, 1,8-cineole and <i>trans</i>-thujone; and in the EO of <i>A. vulgaris</i>, they are <i>trans</i>-thujone and <i>trans</i>-epoxy-ocimene. The EO of the five studied Artemisia species from Croatia is rich in monoterpenoid compounds (1,8-cineole, artemisia ketone, <i>cis</i>-thujone, <i>trans</i>-thujone, <i>cis</i>-epoxy-ocimene, camphor, borneol and <i>cis</i>-sabinyl acetate). The EO of <i>A. arborescens</i> is also rich in chamazulene. The results also showed that the tested EOs have moderate cholinesterase inhibition potential, especially the EOs of <i>A. annua, A. vulgaris</i> and <i>A. abrotanum</i>. This is the first analysis of the chemical composition of the EOs of four <i>Artemisia</i> plants and the first analysis of cholinesterase potential for plants collected in Croatia. |
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| language | English |
| last_indexed | 2024-03-10T20:54:15Z |
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| spelling | doaj.art-f7149c35923947dfadd8543f4a446fc52023-11-19T18:06:44ZengMDPI AGSeparations2297-87392023-10-01101054610.3390/separations10100546Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from CroatiaOlivera Politeo0Ivana Cajic1Anja Simic2Mirko Ruscic3Mejra Bektasevic4Department of Biochemistry, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, CroatiaDepartment of Biochemistry, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, CroatiaDepartment of Biochemistry, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, CroatiaDepartment of Biology, Faculty of Science, University of Split, Ruđera Boškovića 33, 21000 Split, CroatiaDepartment of Biochemistry, Biotechnical Faculty, University of Bihac, Luke Marjanovica bb, Bihac 77000, Bosnia and HerzegovinaThe essential oil (EO) of Artemisia plants contains a large number of bioactive compounds that are widely used. The aim of this study was to analyse the chemical composition of EOs of six Artemisia plants collected in Croatia and to test their cholinesterase inhibitory potential. GC–MS analysis of the EO of <i>A. absinthium</i> showed that the dominant compounds are <i>cis</i>-sabinyl acetate and <i>cis</i>-epoxy-ocimene; in EO of <i>A. abrotanum</i>, it is borneol; in the EO of <i>A. annua</i>, they are artemisia ketone, camphor and 1,8-cineole; in the EO of <i>A. arborescens</i>, they are camphor and chamazulene; in the EO of <i>A. verlotiorum</i>, they are <i>cis</i>-thujone, 1,8-cineole and <i>trans</i>-thujone; and in the EO of <i>A. vulgaris</i>, they are <i>trans</i>-thujone and <i>trans</i>-epoxy-ocimene. The EO of the five studied Artemisia species from Croatia is rich in monoterpenoid compounds (1,8-cineole, artemisia ketone, <i>cis</i>-thujone, <i>trans</i>-thujone, <i>cis</i>-epoxy-ocimene, camphor, borneol and <i>cis</i>-sabinyl acetate). The EO of <i>A. arborescens</i> is also rich in chamazulene. The results also showed that the tested EOs have moderate cholinesterase inhibition potential, especially the EOs of <i>A. annua, A. vulgaris</i> and <i>A. abrotanum</i>. This is the first analysis of the chemical composition of the EOs of four <i>Artemisia</i> plants and the first analysis of cholinesterase potential for plants collected in Croatia.https://www.mdpi.com/2297-8739/10/10/546artemisiaessential oilhydrodistillationGC–MSAChE inhibitionBChE inhibition |
| spellingShingle | Olivera Politeo Ivana Cajic Anja Simic Mirko Ruscic Mejra Bektasevic Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia Separations artemisia essential oil hydrodistillation GC–MS AChE inhibition BChE inhibition |
| title | Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia |
| title_full | Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia |
| title_fullStr | Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia |
| title_full_unstemmed | Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia |
| title_short | Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia |
| title_sort | comparative study of chemical composition and cholinesterase inhibition potential of essential oils isolated from artemisia plants from croatia |
| topic | artemisia essential oil hydrodistillation GC–MS AChE inhibition BChE inhibition |
| url | https://www.mdpi.com/2297-8739/10/10/546 |
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