Association of handgrip strength and walking pace with incident Parkinson's disease
Abstract Background We aimed to quantify the association of handgrip strength and self‐reported walking pace with incident Parkinson's disease (PD) in the general population. Methods A total of 419 572 participants (54.1% females, mean age: 56.1 years [SD, 8.2]) without prior PD were included f...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.13366 |
| _version_ | 1797335226932789248 |
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| author | Mengyi Liu Panpan He Ziliang Ye Yuanyuan Zhang Chun Zhou Sisi Yang Yanjun Zhang Xianhui Qin |
| author_facet | Mengyi Liu Panpan He Ziliang Ye Yuanyuan Zhang Chun Zhou Sisi Yang Yanjun Zhang Xianhui Qin |
| author_sort | Mengyi Liu |
| collection | DOAJ |
| description | Abstract Background We aimed to quantify the association of handgrip strength and self‐reported walking pace with incident Parkinson's disease (PD) in the general population. Methods A total of 419 572 participants (54.1% females, mean age: 56.1 years [SD, 8.2]) without prior PD were included from UK Biobank. Handgrip strength was assessed by dynamometer. Walking pace was self‐reported as slow, average or brisk. The study outcome was incident PD, determined by self‐report data, hospital admission records or death records. Results The mean handgrip strength was 23.5 (SD, 6.3) and 39.6 (SD, 8.9) kg for females and males, respectively. A total of 33 645 (8.0%), 221 682 (52.8%) and 164 245 (39.2%) participants reported slow, average and brisk walking pace, respectively. Over a median follow‐up duration of 12.5 years, 2152 participants developed incident PD. When handgrip strength was assessed as sex‐specific tertiles, compared with those in the third tertile, the adjusted hazard ratios (HRs) (95% confidence interval [CI]) of incident PD for participants in the second and first tertiles were 1.23 (1.09–1.39) and 1.60 (1.42–1.79), respectively. Compared with brisk walking pace, average (HR, 1.33; 95% CI: 1.20–1.47) or slow (HR, 1.84; 95% CI: 1.57–2.15) walking pace was associated with a higher risk of incident PD. A lower grip strength (Tertiles 1 and 2) and an average/slow walking pace accounted for 23.8% and 19.9% of PD cases, respectively. When handgrip strength and walking pace were considered together, the highest risk of incident PD was observed in participants with both lowest handgrip strength and slow walking pace (HR, 2.89; 95% CI: 2.30–3.64). Genetic risks of PD did not significantly modify the relation of handgrip strength (P for interaction = 0.371) or walking pace (P for interaction = 0.082) with new‐onset PD. Conclusions Low handgrip strength and slow walking pace were significantly associated with a higher risk of incident PD, regardless of the individuals' genetic risk profile. |
| first_indexed | 2024-03-08T08:33:52Z |
| format | Article |
| id | doaj.art-f715d0d692764b73bca80b5e837e0fea |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-03-08T08:33:52Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-f715d0d692764b73bca80b5e837e0fea2024-02-02T02:28:29ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092024-02-0115119820710.1002/jcsm.13366Association of handgrip strength and walking pace with incident Parkinson's diseaseMengyi Liu0Panpan He1Ziliang Ye2Yuanyuan Zhang3Chun Zhou4Sisi Yang5Yanjun Zhang6Xianhui Qin7Division of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaDivision of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaDivision of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaDivision of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaDivision of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaDivision of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaDivision of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaDivision of Nephrology Nanfang Hospital, Southern Medical University Guangzhou ChinaAbstract Background We aimed to quantify the association of handgrip strength and self‐reported walking pace with incident Parkinson's disease (PD) in the general population. Methods A total of 419 572 participants (54.1% females, mean age: 56.1 years [SD, 8.2]) without prior PD were included from UK Biobank. Handgrip strength was assessed by dynamometer. Walking pace was self‐reported as slow, average or brisk. The study outcome was incident PD, determined by self‐report data, hospital admission records or death records. Results The mean handgrip strength was 23.5 (SD, 6.3) and 39.6 (SD, 8.9) kg for females and males, respectively. A total of 33 645 (8.0%), 221 682 (52.8%) and 164 245 (39.2%) participants reported slow, average and brisk walking pace, respectively. Over a median follow‐up duration of 12.5 years, 2152 participants developed incident PD. When handgrip strength was assessed as sex‐specific tertiles, compared with those in the third tertile, the adjusted hazard ratios (HRs) (95% confidence interval [CI]) of incident PD for participants in the second and first tertiles were 1.23 (1.09–1.39) and 1.60 (1.42–1.79), respectively. Compared with brisk walking pace, average (HR, 1.33; 95% CI: 1.20–1.47) or slow (HR, 1.84; 95% CI: 1.57–2.15) walking pace was associated with a higher risk of incident PD. A lower grip strength (Tertiles 1 and 2) and an average/slow walking pace accounted for 23.8% and 19.9% of PD cases, respectively. When handgrip strength and walking pace were considered together, the highest risk of incident PD was observed in participants with both lowest handgrip strength and slow walking pace (HR, 2.89; 95% CI: 2.30–3.64). Genetic risks of PD did not significantly modify the relation of handgrip strength (P for interaction = 0.371) or walking pace (P for interaction = 0.082) with new‐onset PD. Conclusions Low handgrip strength and slow walking pace were significantly associated with a higher risk of incident PD, regardless of the individuals' genetic risk profile.https://doi.org/10.1002/jcsm.13366genetic susceptibilityhandgrip strengthParkinson's diseaseUK Biobankwalking pace |
| spellingShingle | Mengyi Liu Panpan He Ziliang Ye Yuanyuan Zhang Chun Zhou Sisi Yang Yanjun Zhang Xianhui Qin Association of handgrip strength and walking pace with incident Parkinson's disease Journal of Cachexia, Sarcopenia and Muscle genetic susceptibility handgrip strength Parkinson's disease UK Biobank walking pace |
| title | Association of handgrip strength and walking pace with incident Parkinson's disease |
| title_full | Association of handgrip strength and walking pace with incident Parkinson's disease |
| title_fullStr | Association of handgrip strength and walking pace with incident Parkinson's disease |
| title_full_unstemmed | Association of handgrip strength and walking pace with incident Parkinson's disease |
| title_short | Association of handgrip strength and walking pace with incident Parkinson's disease |
| title_sort | association of handgrip strength and walking pace with incident parkinson s disease |
| topic | genetic susceptibility handgrip strength Parkinson's disease UK Biobank walking pace |
| url | https://doi.org/10.1002/jcsm.13366 |
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