P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients
Abstract Background Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance. Purpose To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients. Methods 88 patients...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
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| Series: | Artery Research |
| Online Access: | https://doi.org/10.2991/artres.k-191224.169 |
| _version_ | 1797275319742234624 |
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| author | Angela Cozma Adriana Fodor Vasile Negrean Dorel Sampelean Ionut Minciuna Monica Oltean Ionela Popovici Sorina Coste Alexandra Dadarlat Dana Pop Olga Hilda Orasan Adela-Viviana Sitar-Taut |
| author_facet | Angela Cozma Adriana Fodor Vasile Negrean Dorel Sampelean Ionut Minciuna Monica Oltean Ionela Popovici Sorina Coste Alexandra Dadarlat Dana Pop Olga Hilda Orasan Adela-Viviana Sitar-Taut |
| author_sort | Angela Cozma |
| collection | DOAJ |
| description | Abstract Background Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance. Purpose To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients. Methods 88 patients (66 women), mean age 61.96 ± 10.15. Cardiovascular risk factors (body weight, waist circumference, lipid fractions, smoking, diabetes, hypertension) and chemerin were assessed. Insulin resistance scores were calculated: Homeostatic model assessment (HOMA) = insulin (μU/mL)* glicemia (mg/dl)/405 and Quantitative insulin sensitivity check index (QUICKI = 1/[lg10 (insulin (μU/mL)) + lg10 (glicemia)]. Patients were categorized in obese only (20.5%), diabetics only (12.5%), obese and diabetics (14.8%) and non-diabetics-non obese (52.3%). Results 35.3% patients were obese, 27.3% diabetics, 79.5% hypertensive, 17% current smokers, 67% dyslipidaemic. The values of chemerin registered in the four groups were as follows: in diabetic + obese patients 7.98 ± 7.22 pg/ml (median 5.2), diabetics only 7.27 ± 5.24 pg/ml (5.6), obese only 8.42 ± 7.56 pg/ml (median 5.8), non-obese-non-diabetics 9.15 ± 7.64 pg/ml (median 7.15). Globally chemerin did not correlate with waist circumference, HDL-cholesterol, LDL-cholesterol, glicemia, insulin, HOMA index or QUICKI index. Going further with analysis, no significant correlations were found between chemerin and HOMA index and QUICKI index in diabetic + obese patients, obese only patients, diabetics only. But, in non-obese-non-diabetics significant correlations were found — between chemerin and glicemia (r = 0.3), HOMA index (r = 0.3, p = 0.03), QUICKI index (r = -0.310, p = 0.037), but not with waist circumference (r = 0.224, p = NS), HDL (r = 0.08, p = NS) or LDL (r = -0.06, p = NS). Conclusion Although many things need to be elucidated regarding the chemerin mechanism, it seems very probable to be involved in early insulin resistance. |
| first_indexed | 2024-03-07T15:12:38Z |
| format | Article |
| id | doaj.art-f7166f51836f4e64909921e0a0d88817 |
| institution | Directory Open Access Journal |
| issn | 1872-9312 1876-4401 |
| language | English |
| last_indexed | 2024-03-07T15:12:38Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-f7166f51836f4e64909921e0a0d888172024-03-05T18:15:09ZengBMCArtery Research1872-93121876-44012020-02-0125S1S186S18610.2991/artres.k-191224.169P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese PatientsAngela Cozma0Adriana Fodor1Vasile Negrean2Dorel Sampelean3Ionut Minciuna4Monica Oltean5Ionela Popovici6Sorina Coste7Alexandra Dadarlat8Dana Pop9Olga Hilda Orasan10Adela-Viviana Sitar-Taut11University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”University of Medicine and Pharmacy “Iuliu Hatieganu”Abstract Background Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance. Purpose To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients. Methods 88 patients (66 women), mean age 61.96 ± 10.15. Cardiovascular risk factors (body weight, waist circumference, lipid fractions, smoking, diabetes, hypertension) and chemerin were assessed. Insulin resistance scores were calculated: Homeostatic model assessment (HOMA) = insulin (μU/mL)* glicemia (mg/dl)/405 and Quantitative insulin sensitivity check index (QUICKI = 1/[lg10 (insulin (μU/mL)) + lg10 (glicemia)]. Patients were categorized in obese only (20.5%), diabetics only (12.5%), obese and diabetics (14.8%) and non-diabetics-non obese (52.3%). Results 35.3% patients were obese, 27.3% diabetics, 79.5% hypertensive, 17% current smokers, 67% dyslipidaemic. The values of chemerin registered in the four groups were as follows: in diabetic + obese patients 7.98 ± 7.22 pg/ml (median 5.2), diabetics only 7.27 ± 5.24 pg/ml (5.6), obese only 8.42 ± 7.56 pg/ml (median 5.8), non-obese-non-diabetics 9.15 ± 7.64 pg/ml (median 7.15). Globally chemerin did not correlate with waist circumference, HDL-cholesterol, LDL-cholesterol, glicemia, insulin, HOMA index or QUICKI index. Going further with analysis, no significant correlations were found between chemerin and HOMA index and QUICKI index in diabetic + obese patients, obese only patients, diabetics only. But, in non-obese-non-diabetics significant correlations were found — between chemerin and glicemia (r = 0.3), HOMA index (r = 0.3, p = 0.03), QUICKI index (r = -0.310, p = 0.037), but not with waist circumference (r = 0.224, p = NS), HDL (r = 0.08, p = NS) or LDL (r = -0.06, p = NS). Conclusion Although many things need to be elucidated regarding the chemerin mechanism, it seems very probable to be involved in early insulin resistance.https://doi.org/10.2991/artres.k-191224.169 |
| spellingShingle | Angela Cozma Adriana Fodor Vasile Negrean Dorel Sampelean Ionut Minciuna Monica Oltean Ionela Popovici Sorina Coste Alexandra Dadarlat Dana Pop Olga Hilda Orasan Adela-Viviana Sitar-Taut P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients Artery Research |
| title | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_full | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_fullStr | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_full_unstemmed | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_short | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_sort | p149 the relationship between insulin resistance scores parameters and chemerin in diabetic and obese patients |
| url | https://doi.org/10.2991/artres.k-191224.169 |
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