Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade

Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade

Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of...

Full description

Bibliographic Details
Main Authors: Jiao Liu, Rui Kang, Guido Kroemer, Daolin Tang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Adaptive immune resistance
immune checkpoint
molecular chaperone
pancreatic cancer
protein degradation
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2068488
Description
Summary:Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of immunosuppressive indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1/CD274). Pharmacological inhibition of HSP90 enhances the efficacy of programmed cell death 1 (PDCD1/PD-1) targeting immunotherapy in suitable mouse models without any toxicity.
ISSN:2162-402X

Similar Items