Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2068488 |
| _version_ | 1817983725494861824 |
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| author | Jiao Liu Rui Kang Guido Kroemer Daolin Tang |
| author_facet | Jiao Liu Rui Kang Guido Kroemer Daolin Tang |
| author_sort | Jiao Liu |
| collection | DOAJ |
| description | Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of immunosuppressive indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1/CD274). Pharmacological inhibition of HSP90 enhances the efficacy of programmed cell death 1 (PDCD1/PD-1) targeting immunotherapy in suitable mouse models without any toxicity. |
| first_indexed | 2024-04-13T23:36:43Z |
| format | Article |
| id | doaj.art-f716ebf28fb24f5c831fae41082573fe |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-04-13T23:36:43Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-f716ebf28fb24f5c831fae41082573fe2022-12-22T02:24:44ZengTaylor & Francis GroupOncoImmunology2162-402X2022-12-0111110.1080/2162402X.2022.2068488Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockadeJiao Liu0Rui Kang1Guido Kroemer2Daolin Tang3DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong ChinaDepartment of Surgery, UT Southwestern Medical Center, Dallas, Texas USACentre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Paris, FranceDepartment of Surgery, UT Southwestern Medical Center, Dallas, Texas USAInterferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of immunosuppressive indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1/CD274). Pharmacological inhibition of HSP90 enhances the efficacy of programmed cell death 1 (PDCD1/PD-1) targeting immunotherapy in suitable mouse models without any toxicity.https://www.tandfonline.com/doi/10.1080/2162402X.2022.2068488Adaptive immune resistanceimmune checkpointmolecular chaperonepancreatic cancerprotein degradation |
| spellingShingle | Jiao Liu Rui Kang Guido Kroemer Daolin Tang Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade OncoImmunology Adaptive immune resistance immune checkpoint molecular chaperone pancreatic cancer protein degradation |
| title | Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade |
| title_full | Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade |
| title_fullStr | Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade |
| title_full_unstemmed | Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade |
| title_short | Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade |
| title_sort | targeting hsp90 sensitizes pancreas carcinoma to pd 1 blockade |
| topic | Adaptive immune resistance immune checkpoint molecular chaperone pancreatic cancer protein degradation |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2068488 |
| work_keys_str_mv | AT jiaoliu targetinghsp90sensitizespancreascarcinomatopd1blockade AT ruikang targetinghsp90sensitizespancreascarcinomatopd1blockade AT guidokroemer targetinghsp90sensitizespancreascarcinomatopd1blockade AT daolintang targetinghsp90sensitizespancreascarcinomatopd1blockade |