Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective
Topoisomerase I inhibitors represent a widely used class of antineoplastic agents that promote both single-stranded and double-stranded breaks in the DNA of tumor cells, leading to tumor cell death. Topotecan and irinotecan are the clinically relevant derivatives of the parent drug, camptothecin. As...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Autophagy Reports |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/27694127.2022.2155904 |
| _version_ | 1797685744919117824 |
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| author | Ahmed M. Elshazly Polina A. Wright Jingwen Xu David A. Gewirtz |
| author_facet | Ahmed M. Elshazly Polina A. Wright Jingwen Xu David A. Gewirtz |
| author_sort | Ahmed M. Elshazly |
| collection | DOAJ |
| description | Topoisomerase I inhibitors represent a widely used class of antineoplastic agents that promote both single-stranded and double-stranded breaks in the DNA of tumor cells, leading to tumor cell death. Topotecan and irinotecan are the clinically relevant derivatives of the parent drug, camptothecin. As is the case with many if not most anticancer agents, irinotecan and topotecan promote autophagy. However, whether the autophagy is cytotoxic, cytoprotective, or non-protective is not clearly defined, and may depend largely upon the genetic background of the tumor cell being investigated. This review explores the available literature regarding the nature of the autophagy induced by these clinically utilized topoisomerase I inhibitors in preclinical tumor models with the goal of determining whether the targeting of autophagy might have potential as a therapeutic strategy to enhance the antitumor response and/or overcome drug resistance. |
| first_indexed | 2024-03-12T00:55:47Z |
| format | Article |
| id | doaj.art-f71762f0db744e1ca5af4fc997ccbde9 |
| institution | Directory Open Access Journal |
| issn | 2769-4127 |
| language | English |
| last_indexed | 2024-03-12T00:55:47Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj.art-f71762f0db744e1ca5af4fc997ccbde92023-09-14T13:24:40ZengTaylor & Francis GroupAutophagy Reports2769-41272023-12-012111610.1080/27694127.2022.21559042155904Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protectiveAhmed M. Elshazly0Polina A. Wright1Jingwen Xu2David A. Gewirtz3Virginia Commonwealth University, Massey Cancer CenterVirginia Commonwealth University, Massey Cancer CenterSchool of Pharmacy, Guangdong Pharmaceutical UniversityVirginia Commonwealth University, Massey Cancer CenterTopoisomerase I inhibitors represent a widely used class of antineoplastic agents that promote both single-stranded and double-stranded breaks in the DNA of tumor cells, leading to tumor cell death. Topotecan and irinotecan are the clinically relevant derivatives of the parent drug, camptothecin. As is the case with many if not most anticancer agents, irinotecan and topotecan promote autophagy. However, whether the autophagy is cytotoxic, cytoprotective, or non-protective is not clearly defined, and may depend largely upon the genetic background of the tumor cell being investigated. This review explores the available literature regarding the nature of the autophagy induced by these clinically utilized topoisomerase I inhibitors in preclinical tumor models with the goal of determining whether the targeting of autophagy might have potential as a therapeutic strategy to enhance the antitumor response and/or overcome drug resistance.http://dx.doi.org/10.1080/27694127.2022.2155904irinotecantopotecanautophagycytoprotectivecytotoxicnon-protective |
| spellingShingle | Ahmed M. Elshazly Polina A. Wright Jingwen Xu David A. Gewirtz Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective Autophagy Reports irinotecan topotecan autophagy cytoprotective cytotoxic non-protective |
| title | Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective |
| title_full | Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective |
| title_fullStr | Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective |
| title_full_unstemmed | Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective |
| title_short | Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective |
| title_sort | topoisomerase i poisons induced autophagy cytoprotective cytotoxic or non protective |
| topic | irinotecan topotecan autophagy cytoprotective cytotoxic non-protective |
| url | http://dx.doi.org/10.1080/27694127.2022.2155904 |
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