Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals
Abstract Short nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime slee...
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Format: | Article |
Language: | English |
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Nature Publishing Group
2023-02-01
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Series: | Translational Psychiatry |
Online Access: | https://doi.org/10.1038/s41398-023-02334-4 |
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author | Pei Xue Ilona Merikanto Frances Chung Charles M. Morin Colin Espie Bjørn Bjorvatn Jonathan Cedernaes Anne-Marie Landtblom Thomas Penzel Luigi De Gennaro Brigitte Holzinger Kentaro Matsui Harald Hrubos-Strøm Maria Korman Damien Leger Sérgio Mota-Rolim Courtney J. Bolstad Michael Nadorff Giuseppe Plazzi Catia Reis Rachel Ngan Yin Chan Yun Kwok Wing Juliana Yordanova Adrijana Koscec Bjelajac Yuichi Inoue Markku Partinen Yves Dauvilliers Christian Benedict |
author_facet | Pei Xue Ilona Merikanto Frances Chung Charles M. Morin Colin Espie Bjørn Bjorvatn Jonathan Cedernaes Anne-Marie Landtblom Thomas Penzel Luigi De Gennaro Brigitte Holzinger Kentaro Matsui Harald Hrubos-Strøm Maria Korman Damien Leger Sérgio Mota-Rolim Courtney J. Bolstad Michael Nadorff Giuseppe Plazzi Catia Reis Rachel Ngan Yin Chan Yun Kwok Wing Juliana Yordanova Adrijana Koscec Bjelajac Yuichi Inoue Markku Partinen Yves Dauvilliers Christian Benedict |
author_sort | Pei Xue |
collection | DOAJ |
description | Abstract Short nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18–99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection. |
first_indexed | 2024-04-10T17:16:46Z |
format | Article |
id | doaj.art-f717aea8371a43d59506d2eb1e7c6d31 |
institution | Directory Open Access Journal |
issn | 2158-3188 |
language | English |
last_indexed | 2024-04-10T17:16:46Z |
publishDate | 2023-02-01 |
publisher | Nature Publishing Group |
record_format | Article |
series | Translational Psychiatry |
spelling | doaj.art-f717aea8371a43d59506d2eb1e7c6d312023-02-05T12:24:37ZengNature Publishing GroupTranslational Psychiatry2158-31882023-02-011311710.1038/s41398-023-02334-4Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individualsPei Xue0Ilona Merikanto1Frances Chung2Charles M. Morin3Colin Espie4Bjørn Bjorvatn5Jonathan Cedernaes6Anne-Marie Landtblom7Thomas Penzel8Luigi De Gennaro9Brigitte Holzinger10Kentaro Matsui11Harald Hrubos-Strøm12Maria Korman13Damien Leger14Sérgio Mota-Rolim15Courtney J. Bolstad16Michael Nadorff17Giuseppe Plazzi18Catia Reis19Rachel Ngan Yin Chan20Yun Kwok Wing21Juliana Yordanova22Adrijana Koscec Bjelajac23Yuichi Inoue24Markku Partinen25Yves Dauvilliers26Christian Benedict27Department of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala UniversityResearch Programs Unit, Faculty of Medicine, University of HelsinkiDepartment of Anesthesiology and Pain Medicine, University Health Network, University of TorontoCentre de recherche CERVO/Brain Research Center, École de psychologie, Université LavalSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of OxfordDepartment of Global Public Health and Primary Care, University of BergenDepartment of Medical Sciences, Transplantation and regenerative medicine, Uppsala UniversityDepartment of Medical Sciences, Neurology, Uppsala UniversitySleep Medicine Center, Charite University Hospital BerlinDepartment of Psychology, Sapienza University of RomeInstitute for Consciousness and Dream Research; Medical University of Vienna, Wien, Postgraduate Sleep CoachingDepartment of Clinical Laboratory, National Center Hospital, National Center of Neurology and PsychiatryDepartment of Otorhinolaryngology, Akershus University HospitalDepartment of Occupational Therapy, Faculty of Health Sciences, Ariel UniversitySleep and Vigilance Center, Hopital Hotel-Dieu de ParisBrain Institute, Onofre Lopes University Hospital, and Physiology and Behavior Department, Federal University of Rio Grande do NorteDepartment of Psychology, Mississippi State University, Mississippi StateDepartment of Psychology, Mississippi State University, Mississippi StateIRCCS Istituto Delle Scienze Neurologiche di BolognaUniversidade Católica Portuguesa, Católica Research Centre for Psychological - Family and Social WellbeingLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongInstitute of Neurobiology, Bulgarian Academy of SciencesInstitute for Medical Research and Occupational HealthDepartment of Somnology, Tokyo Medical UniversityDepartment of Clinical Neurosciences, University of Helsinki Clinicum UnitSleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, Institute for Neurosciences of Montpellier INM, INSERM, University of MontpellierDepartment of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala UniversityAbstract Short nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18–99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection.https://doi.org/10.1038/s41398-023-02334-4 |
spellingShingle | Pei Xue Ilona Merikanto Frances Chung Charles M. Morin Colin Espie Bjørn Bjorvatn Jonathan Cedernaes Anne-Marie Landtblom Thomas Penzel Luigi De Gennaro Brigitte Holzinger Kentaro Matsui Harald Hrubos-Strøm Maria Korman Damien Leger Sérgio Mota-Rolim Courtney J. Bolstad Michael Nadorff Giuseppe Plazzi Catia Reis Rachel Ngan Yin Chan Yun Kwok Wing Juliana Yordanova Adrijana Koscec Bjelajac Yuichi Inoue Markku Partinen Yves Dauvilliers Christian Benedict Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals Translational Psychiatry |
title | Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_full | Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_fullStr | Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_full_unstemmed | Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_short | Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_sort | persistent short nighttime sleep duration is associated with a greater post covid risk in fully mrna vaccinated individuals |
url | https://doi.org/10.1038/s41398-023-02334-4 |
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